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pubmed-article:11325469pubmed:abstractTextThe secretory glycoprotein (Gs) of respiratory syncytial virus (RSV) was enriched and investigated for its effects on T cells specific for RSV and unrelated antigens. Gs exhibited a dose dependent suppression of lymphoproliferative responses in peripheral blood mononuclear cells (PBMCs), specific for mycobacterial lysates or tetanus toxoid. However, Gs did not inhibit live RSV specific T cell responses. These results suggest that Gs may suppress immune response to unrelated antigens, but should not interfere with the overall development of RSV specific immunity.lld:pubmed
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pubmed-article:11325469pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:11325469pubmed:articleTitleImmunoregulatory role of secreted glycoprotein G from respiratory syncytial virus.lld:pubmed
pubmed-article:11325469pubmed:affiliationDivision of Infectious Diseases and Immunology, Saint Louis University, 3635 Vista Avenue, St. Louis, MO 63110, USA. rayr@slu.edulld:pubmed
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pubmed-article:11325469pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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