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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5514
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pubmed:dateCreated |
2001-4-9
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pubmed:abstractText |
The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2, a signal transducer regulating worm dauer formation and adult longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced late age-specific mortality. Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy toward that of wild-type controls. We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/InR protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Juvenile Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Methoprene,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
292
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11292875-Aging,
pubmed-meshheading:11292875-Alleles,
pubmed-meshheading:11292875-Animals,
pubmed-meshheading:11292875-Carrier Proteins,
pubmed-meshheading:11292875-Corpora Allata,
pubmed-meshheading:11292875-Drosophila Proteins,
pubmed-meshheading:11292875-Drosophila melanogaster,
pubmed-meshheading:11292875-Female,
pubmed-meshheading:11292875-Fertility,
pubmed-meshheading:11292875-Genes, Insect,
pubmed-meshheading:11292875-Genotype,
pubmed-meshheading:11292875-Insulin,
pubmed-meshheading:11292875-Juvenile Hormones,
pubmed-meshheading:11292875-Longevity,
pubmed-meshheading:11292875-Male,
pubmed-meshheading:11292875-Methoprene,
pubmed-meshheading:11292875-Mutation,
pubmed-meshheading:11292875-Protein-Tyrosine Kinases,
pubmed-meshheading:11292875-Receptor, Insulin,
pubmed-meshheading:11292875-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:11292875-Reproduction,
pubmed-meshheading:11292875-Signal Transduction,
pubmed-meshheading:11292875-Superoxide Dismutase,
pubmed-meshheading:11292875-Triglycerides,
pubmed-meshheading:11292875-Vitellogenesis
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pubmed:year |
2001
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pubmed:articleTitle |
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
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pubmed:affiliation |
Brown University, Providence, RI 02912, USA., University of Massachusetts, Amherst, MA 01003, USA. Marc_Tatar@Brown.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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