Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-4-3
pubmed:abstractText
Immunocyte-derived beta-endorphin can activate peripheral opioid receptors on sensory neurons to inhibit pain within inflamed tissue. This study examined mu-opioid receptors (MOR) on sensory nerves and beta-endorphin (END) in activated/memory CD4(+) cells (the predominant population homing to inflamed tissue). We found an upregulation of MOR in dorsal root ganglia, an increased axonal transport of MOR in the sciatic nerve and an accumulation of MOR in peripheral nerve terminals in Freund's adjuvant-induced hindpaw inflammation. A large number of CD4(+) cells containing beta-endorphin, but very few naive cells (CD45RC(+)), were observed in inflamed tissue, suggesting that this opioid is mainly present in activated/memory cells (CD4(+)/CD45RC(-)). Taken together, our results indicate an enhanced transport of both MOR and of the endogenous ligand beta-endorphin to injured tissue. This unique simultaneous upregulation of both receptors and ligands may serve to prevent excessive and/or chronic inflammatory pain.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11282156-Animals, pubmed-meshheading:11282156-Axonal Transport, pubmed-meshheading:11282156-Blotting, Western, pubmed-meshheading:11282156-CD4-Positive T-Lymphocytes, pubmed-meshheading:11282156-Disease Models, Animal, pubmed-meshheading:11282156-Freund's Adjuvant, pubmed-meshheading:11282156-Ganglia, Spinal, pubmed-meshheading:11282156-Hindlimb, pubmed-meshheading:11282156-Immunologic Memory, pubmed-meshheading:11282156-Inflammation, pubmed-meshheading:11282156-Ligation, pubmed-meshheading:11282156-Male, pubmed-meshheading:11282156-Neurons, Afferent, pubmed-meshheading:11282156-Rats, pubmed-meshheading:11282156-Rats, Wistar, pubmed-meshheading:11282156-Receptors, Opioid, mu, pubmed-meshheading:11282156-Sciatic Nerve, pubmed-meshheading:11282156-Skin, pubmed-meshheading:11282156-beta-Endorphin
pubmed:year
2001
pubmed:articleTitle
beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue.
pubmed:affiliation
Klinik für Anaesthesiologie und Operative Intensivmedizin, Freie Universität Berlin, Hindenburgdamm 30, D-12200, Berlin, Germany. Shaaban@zop-admin.ukbf.fu-berlin.de
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't