| pubmed-article:11245414 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11245414 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11245414 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:11245414 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:11245414 | lifeskim:mentions | umls-concept:C0533670 | lld:lifeskim |
| pubmed-article:11245414 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11245414 | lifeskim:mentions | umls-concept:C0598934 | lld:lifeskim |
| pubmed-article:11245414 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11245414 | pubmed:dateCreated | 2001-3-13 | lld:pubmed |
| pubmed-article:11245414 | pubmed:abstractText | Angiopoietin (Ang) 1 and Ang-2 are important regulators of endothelial cell survival. Current models suggest that an increase in Ang-2 expression in endothelial cells leads to initiation of angiogenesis. We stably transfected HT29 colon cancer cells with cDNA constructs for Ang-1 or -2 or with vector alone, injected the cells s.c. into nude mice, and assessed tumor growth. Immunohistochemical analyses confirmed sustained increases of Ang-1 and -2 in the tumors. The tumors produced by the Ang-2-transfected cells were larger than the tumors produced in the other groups; those tumors also had higher vessel counts and proliferative indices than tumors in the other groups. Tumors produced by the Ang-1 transfectants had fewer vessels and lower tumor cell proliferative indices than tumors in the other groups. These data suggest that imbalances between Ang-1 and -2 that result in a net gain of Ang-2 activity lead to enhanced tumor angiogenesis and growth. | lld:pubmed |
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| pubmed-article:11245414 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11245414 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11245414 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11245414 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11245414 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11245414 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:LiuWW | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:WilsonMM | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:EllisL MLM | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:BucanaC DCD | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:AhmadS ASA | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:FanFF | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:ShaheenR MRM | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:ReinmuthNN | lld:pubmed |
| pubmed-article:11245414 | pubmed:author | pubmed-author:JungY DYD | lld:pubmed |
| pubmed-article:11245414 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11245414 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11245414 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:11245414 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11245414 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11245414 | pubmed:pagination | 1255-9 | lld:pubmed |
| pubmed-article:11245414 | pubmed:dateRevised | 2011-8-3 | lld:pubmed |
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| pubmed-article:11245414 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11245414 | pubmed:articleTitle | The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer. | lld:pubmed |
| pubmed-article:11245414 | pubmed:affiliation | Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. | lld:pubmed |
| pubmed-article:11245414 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11245414 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11245414 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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