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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-3-13
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pubmed:abstractText |
Angiopoietin (Ang) 1 and Ang-2 are important regulators of endothelial cell survival. Current models suggest that an increase in Ang-2 expression in endothelial cells leads to initiation of angiogenesis. We stably transfected HT29 colon cancer cells with cDNA constructs for Ang-1 or -2 or with vector alone, injected the cells s.c. into nude mice, and assessed tumor growth. Immunohistochemical analyses confirmed sustained increases of Ang-1 and -2 in the tumors. The tumors produced by the Ang-2-transfected cells were larger than the tumors produced in the other groups; those tumors also had higher vessel counts and proliferative indices than tumors in the other groups. Tumors produced by the Ang-1 transfectants had fewer vessels and lower tumor cell proliferative indices than tumors in the other groups. These data suggest that imbalances between Ang-1 and -2 that result in a net gain of Ang-2 activity lead to enhanced tumor angiogenesis and growth.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1255-9
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:11245414-Angiopoietin-1,
pubmed-meshheading:11245414-Angiopoietin-2,
pubmed-meshheading:11245414-Animals,
pubmed-meshheading:11245414-Apoptosis,
pubmed-meshheading:11245414-Blotting, Northern,
pubmed-meshheading:11245414-Cell Division,
pubmed-meshheading:11245414-Colonic Neoplasms,
pubmed-meshheading:11245414-Endothelium, Vascular,
pubmed-meshheading:11245414-HT29 Cells,
pubmed-meshheading:11245414-Humans,
pubmed-meshheading:11245414-Male,
pubmed-meshheading:11245414-Membrane Glycoproteins,
pubmed-meshheading:11245414-Mice,
pubmed-meshheading:11245414-Mice, Nude,
pubmed-meshheading:11245414-Neoplasm Transplantation,
pubmed-meshheading:11245414-Neovascularization, Pathologic,
pubmed-meshheading:11245414-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:11245414-Protein Biosynthesis,
pubmed-meshheading:11245414-Proteins,
pubmed-meshheading:11245414-Transfection,
pubmed-meshheading:11245414-Transplantation, Heterologous
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pubmed:year |
2001
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pubmed:articleTitle |
The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer.
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pubmed:affiliation |
Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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