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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
211
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pubmed:dateCreated |
2001-3-7
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pubmed:abstractText |
There are very few data concerning the role played by cell-mediated cytotoxicity, particularly at the molecular level, in the course of psoriasis. Both cytotoxic T lymphocytes (CTL) and natural killer cells contain in their granules the cytolytic protein perforin, a mediator in cell-mediated cytotoxicity reactions. The aim of this study was to analyze perforin expression in various sets and subsets of perforin-positive peripheral blood lymphocytes in 17 patients with chronic psoriasis vulgaris in the exacerbation phase. The results were compared with those of an age- and sex-matched healthy control group (n = 21). Perforin (intracellular antigen) and cell surface antigens were detected using the simultaneous double-staining method. We found a significant increase in perforin (P) expression in the patient group for CTL (CD3+P+ cells), which are located mostly in the CD8+ population of T lymphocytes (CD8+P+).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0365-8341
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11234556-Acute Disease,
pubmed-meshheading:11234556-Adult,
pubmed-meshheading:11234556-Antibodies, Monoclonal,
pubmed-meshheading:11234556-Antigens, Surface,
pubmed-meshheading:11234556-Case-Control Studies,
pubmed-meshheading:11234556-Female,
pubmed-meshheading:11234556-Flow Cytometry,
pubmed-meshheading:11234556-Humans,
pubmed-meshheading:11234556-Killer Cells, Natural,
pubmed-meshheading:11234556-Male,
pubmed-meshheading:11234556-Membrane Glycoproteins,
pubmed-meshheading:11234556-Middle Aged,
pubmed-meshheading:11234556-Perforin,
pubmed-meshheading:11234556-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:11234556-Psoriasis,
pubmed-meshheading:11234556-T-Lymphocyte Subsets,
pubmed-meshheading:11234556-T-Lymphocytes, Cytotoxic
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pubmed:year |
2000
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pubmed:articleTitle |
Assessment of perforin expression in peripheral blood lymphocytes in psoriatic patients during exacerbation of disease.
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pubmed:affiliation |
Department of Dermatovenerology, Medical Faculty, University of Rijeka, Rijeka, Croatia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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