| pubmed-article:11223654 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11223654 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:11223654 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11223654 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11223654 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:11223654 | lifeskim:mentions | umls-concept:C0006121 | lld:lifeskim |
| pubmed-article:11223654 | lifeskim:mentions | umls-concept:C0425449 | lld:lifeskim |
| pubmed-article:11223654 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11223654 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:11223654 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11223654 | pubmed:dateCreated | 2001-3-6 | lld:pubmed |
| pubmed-article:11223654 | pubmed:abstractText | Gasping is an important mechanism for survival that appears to be developmentally modulated by the glutamate-nitric oxide (NO) pathway. However, the temporal characteristics of NO brain tissue levels during gasping are unknown. We hypothesized that during anoxia-induced gasping, the gasping frequency would be closely correlated with caudal brainstem tissue NO concentrations in developing rats. Brainstem and cortical tissue NO levels were measured during anoxia using a voltammetric electrode in adult rats and 5-day-old pups during control conditions and following pretreatment with the NMDA receptor antagonist MK-801 (1 mg/kg) or the neuronal NO synthase inhibitor 7-nitro-indazole (7-NI; 100 mg/kg). In young animals, NO tissue levels followed a triphasic trajectory coincident with gasp frequency which was markedly altered by MK-801 and 7-NI, albeit with preservation of gasp frequency-NO tissue level relationships. In adult rats, 40-fold higher NO tissue levels occurred and followed a monophasic trajectory coincident with gasp patterning. In the cortex, monophasic increases in NO levels occurred at all ages. We conclude that anoxia-induced gasping neurogenesis is modulated via NMDA-NO mechanisms in the developing rat. We postulate that higher NO brainstem concentrations may favor early autoresuscitation, but limit anoxic tolerance. | lld:pubmed |
| pubmed-article:11223654 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11223654 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11223654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11223654 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11223654 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11223654 | pubmed:issn | 0006-3126 | lld:pubmed |
| pubmed-article:11223654 | pubmed:author | pubmed-author:TorresJ EJE | lld:pubmed |
| pubmed-article:11223654 | pubmed:author | pubmed-author:GreenG SGS | lld:pubmed |
| pubmed-article:11223654 | pubmed:copyrightInfo | Copyright 2001 S. Karger AG, Basel | lld:pubmed |
| pubmed-article:11223654 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11223654 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:11223654 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11223654 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11223654 | pubmed:pagination | 122-30 | lld:pubmed |
| pubmed-article:11223654 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11223654 | pubmed:meshHeading | pubmed-meshheading:11223654... | lld:pubmed |
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| pubmed-article:11223654 | pubmed:meshHeading | pubmed-meshheading:11223654... | lld:pubmed |
| pubmed-article:11223654 | pubmed:meshHeading | pubmed-meshheading:11223654... | lld:pubmed |
| pubmed-article:11223654 | pubmed:meshHeading | pubmed-meshheading:11223654... | lld:pubmed |
| pubmed-article:11223654 | pubmed:meshHeading | pubmed-meshheading:11223654... | lld:pubmed |
| pubmed-article:11223654 | pubmed:meshHeading | pubmed-meshheading:11223654... | lld:pubmed |
| pubmed-article:11223654 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11223654 | pubmed:articleTitle | Brainstem nitric oxide tissue levels correlate with anoxia-induced gasping activity in the developing rat. | lld:pubmed |
| pubmed-article:11223654 | pubmed:affiliation | Kosair Children's Hospital Research Institute, Departments of Pediatrics, Pharmacology and Toxicology, University of Louisville School of Medicine, KY 40202, USA. d0goza01@gwise.louisville.edu | lld:pubmed |
| pubmed-article:11223654 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11223654 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11223654 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11223654 | lld:pubmed |
