Source:http://linkedlifedata.com/resource/pubmed/id/11223654
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-3-6
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| pubmed:abstractText |
Gasping is an important mechanism for survival that appears to be developmentally modulated by the glutamate-nitric oxide (NO) pathway. However, the temporal characteristics of NO brain tissue levels during gasping are unknown. We hypothesized that during anoxia-induced gasping, the gasping frequency would be closely correlated with caudal brainstem tissue NO concentrations in developing rats. Brainstem and cortical tissue NO levels were measured during anoxia using a voltammetric electrode in adult rats and 5-day-old pups during control conditions and following pretreatment with the NMDA receptor antagonist MK-801 (1 mg/kg) or the neuronal NO synthase inhibitor 7-nitro-indazole (7-NI; 100 mg/kg). In young animals, NO tissue levels followed a triphasic trajectory coincident with gasp frequency which was markedly altered by MK-801 and 7-NI, albeit with preservation of gasp frequency-NO tissue level relationships. In adult rats, 40-fold higher NO tissue levels occurred and followed a monophasic trajectory coincident with gasp patterning. In the cortex, monophasic increases in NO levels occurred at all ages. We conclude that anoxia-induced gasping neurogenesis is modulated via NMDA-NO mechanisms in the developing rat. We postulate that higher NO brainstem concentrations may favor early autoresuscitation, but limit anoxic tolerance.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-nitroindazole,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Indazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0006-3126
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 S. Karger AG, Basel
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| pubmed:issnType |
Print
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| pubmed:volume |
79
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
122-30
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11223654-Aging,
pubmed-meshheading:11223654-Animals,
pubmed-meshheading:11223654-Animals, Newborn,
pubmed-meshheading:11223654-Anoxia,
pubmed-meshheading:11223654-Brain Stem,
pubmed-meshheading:11223654-Dizocilpine Maleate,
pubmed-meshheading:11223654-Enzyme Inhibitors,
pubmed-meshheading:11223654-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11223654-Indazoles,
pubmed-meshheading:11223654-Neocortex,
pubmed-meshheading:11223654-Nitric Oxide,
pubmed-meshheading:11223654-Nitric Oxide Synthase,
pubmed-meshheading:11223654-Osmolar Concentration,
pubmed-meshheading:11223654-Rats,
pubmed-meshheading:11223654-Rats, Sprague-Dawley,
pubmed-meshheading:11223654-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:11223654-Respiration,
pubmed-meshheading:11223654-Respiration Disorders
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| pubmed:year |
2001
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| pubmed:articleTitle |
Brainstem nitric oxide tissue levels correlate with anoxia-induced gasping activity in the developing rat.
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| pubmed:affiliation |
Kosair Children's Hospital Research Institute, Departments of Pediatrics, Pharmacology and Toxicology, University of Louisville School of Medicine, KY 40202, USA. d0goza01@gwise.louisville.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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