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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-30
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pubmed:abstractText |
Presenilin-2 (PS2; AD4), a regulator of intercellular signaling during CNS development and cell fate determination, appears to be involved in pathogenic processing of beta-amyloid precursor protein (betaAPP) into potentially neurotoxic beta-amyloid (Abeta) peptides. The PS2 gene promoter contains multiple DNA binding sites for the relatively rare hypoxia-inducible transcription factor HIF-1, suggesting that PS2 expression may be a sensitive indicator of decreased oxygen availability. We have used a cycled hypoxia/hyperoxia (10-50% O2) protocol followed by normoxia (20% O2) as a retinal model of retinopathy of prematurity to induce neovascularization (NV) in rat pups. Retinal cell nuclear extracts from pups undergoing hypoxia exhibited a dramatic increase in HIF-1-DNA binding, followed by a delayed (2-7 day) elevation of PS2 RNA message and protein. PS2 gene activation during hypoxia may direct cellular fate towards pathoangiogenesis and intercellular PS2-mediated signaling dysfunction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hif1a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PSEN2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Presenilin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11201091-Animals,
pubmed-meshheading:11201091-Animals, Newborn,
pubmed-meshheading:11201091-DNA-Binding Proteins,
pubmed-meshheading:11201091-Disease Models, Animal,
pubmed-meshheading:11201091-Female,
pubmed-meshheading:11201091-Gene Expression,
pubmed-meshheading:11201091-Humans,
pubmed-meshheading:11201091-Hypoxia-Inducible Factor 1,
pubmed-meshheading:11201091-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:11201091-Infant, Newborn,
pubmed-meshheading:11201091-Membrane Proteins,
pubmed-meshheading:11201091-Nuclear Proteins,
pubmed-meshheading:11201091-Pregnancy,
pubmed-meshheading:11201091-Presenilin-2,
pubmed-meshheading:11201091-Rats,
pubmed-meshheading:11201091-Retina,
pubmed-meshheading:11201091-Retinal Neovascularization,
pubmed-meshheading:11201091-Retinopathy of Prematurity,
pubmed-meshheading:11201091-Transcription Factors,
pubmed-meshheading:11201091-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis.
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pubmed:affiliation |
Neuroscience Center and Department of Ophthalmology, Louisiana State University School of Medicine, New Orleans 70112-2272, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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