Linked Life Data

11180806

Source:http://linkedlifedata.com/resource/pubmed/id/11180806

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-2-22
pubmed:abstractText
Drosophila embryos lacking the homeotic gene labial (lab) show two types of defects in brain development: (1) cells in the brain lab domain do not express neuronal markers or extend axons, and (2) axons originating from outside the lab domain stop at this region or project ectopically. A severe disruption of neuronal patterning and axon scaffolding is the net result. It is not clear how the absence of Lab can result in both neuronal fate defects and axon pathfinding defects. I have expressed Lab in short pulses in lab loss-of- function embryos, and this gave almost complete rescue; for example, the tritocerebral commissure was restored. Rescue only occurred when Lab was provided at the time when cells in the brain are adopting a neuronal fate. Lab expression later, when the first axons are seen in the lab domain, did not give rescue. I conclude that Lab expression helps to establish neuronal identity in the lab domain, and these neurons act as a permissive substrate for axon extension. However, Lab itself is not required at the time of axon pathfinding through this region.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0949-944X
pubmed:author
pubmed:issnType
Print
pubmed:volume
210
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
559-63
pubmed:dateRevised
2008-10-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
labial acts to initiate neuronal fate specification, but not axon pathfinding, in the embryonic brain of Drosophila.
pubmed:affiliation
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. paged@mrc-lmb.cam.ac.uk
pubmed:publicationType
Journal Article