Linked Life Data

11180637

Source:http://linkedlifedata.com/resource/pubmed/id/11180637

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-2-22
pubmed:abstractText
The nitrogen blister agents HN-2 (bis(2-chloroethyl)methylamine) and HN-3 (tris(2-chloroethyl)amine) were directly analyzed on the surface of soil samples using ion trap secondary ion mass spectrometry (SIMS). In the presence of water, HN-1 (bis(2-choroethyl)ethylamine), HN-2 and HN-3 undergo hydrolysis to form N-ethyldiethanolamine, N-methyldiethanolamine and triethanolamine (TEA), respectively; these compounds can be readily detected as adsorbed species on soil particles. When soil samples spiked with HN-3 in alcohol were analyzed, 2-alkoxyethylamine derivatives were observed on the sample surfaces. This result shows that nitrogen blister agents will undergo condensation reactions with nucleophilic compounds and emphasizes the need for an analytical methodology capable of detecting a range of degradation and condensation products on environmental surfaces. The ability of ion trap SIMS to isolate and accumulate ions, and then perform tandem mass spectrometric analysis improves the detection of low-abundance surface contaminants and the selectivity of the technique. Utilizing these techniques, the limits of detection for HN-3 were studied as a function of surface coverage. It was found that HN-3 could be detected at a surface coverage of 0.01 monolayer, which corresponds to 20 ppm (mass/mass) for a soil having a surface area of 2.2 m(2) g(-1). TEA, the exhaustive hydrolysis product of HN-3, was detected at a surface coverage of 0.001 monolayer, which corresponds to 0.86 ppm.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/2,2',2''-trichlorotriethylamine, http://linkedlifedata.com/resource/pubmed/chemical/3,4-Methylenedioxyamphetamine, http://linkedlifedata.com/resource/pubmed/chemical/3,4-methylenedioxyethamphetamine, http://linkedlifedata.com/resource/pubmed/chemical/Chemical Warfare Agents, http://linkedlifedata.com/resource/pubmed/chemical/Ethanolamines, http://linkedlifedata.com/resource/pubmed/chemical/Irritants, http://linkedlifedata.com/resource/pubmed/chemical/Mechlorethamine, http://linkedlifedata.com/resource/pubmed/chemical/N-methyldiethanolamine, http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen Mustard Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Soil, http://linkedlifedata.com/resource/pubmed/chemical/triethanolamine
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1076-5174
pubmed:author
pubmed:copyrightInfo
Copyright 2000 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1460-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry.
pubmed:affiliation
Idaho National Engineering and Environmental Laboratory, P.O. Box 1625, Idaho Falls, Idaho 83415-2208, USA. vrn@inel.gov
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.