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pubmed-article:11179386pubmed:abstractTextMeningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.lld:pubmed
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pubmed-article:11179386pubmed:articleTitleCircumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the porA gene of Neisseria meningitidis.lld:pubmed
pubmed-article:11179386pubmed:affiliationUnité des Neisseria and Centre National de Référence des Méningocoques, Institut Pasteur, 75724 Paris Cedex 15, France. mktaha@pasteur.frlld:pubmed
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