|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2001-2-26
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0019-9567
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
69
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1971-3
|
|
pubmed:dateRevised |
2011-4-7
|
|
pubmed:meshHeading |
pubmed-meshheading:11179386-Disease Outbreaks,
pubmed-meshheading:11179386-France,
pubmed-meshheading:11179386-Humans,
pubmed-meshheading:11179386-Meningococcal Infections,
pubmed-meshheading:11179386-Meningococcal Vaccines,
pubmed-meshheading:11179386-Molecular Epidemiology,
pubmed-meshheading:11179386-Molecular Sequence Data,
pubmed-meshheading:11179386-Mutation,
pubmed-meshheading:11179386-Neisseria meningitidis,
pubmed-meshheading:11179386-Polymerase Chain Reaction,
pubmed-meshheading:11179386-Porins,
pubmed-meshheading:11179386-Sequence Analysis, DNA
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the porA gene of Neisseria meningitidis.
|
|
pubmed:affiliation |
Unité des Neisseria and Centre National de Référence des Méningocoques, Institut Pasteur, 75724 Paris Cedex 15, France. mktaha@pasteur.fr
|
|
pubmed:publicationType |
Journal Article
|
