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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier. TNF-alpha has been shown to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. To model elevated TNF-alpha in AIDS dementia complex, TNF-alpha was infused ICV bilaterally into rats for 3 days. TNF-alpha treatment increased apoptosis around the infusion site and selectively in the septum and corpus callosum. Co-administration of the synthetic antioxidant CPI-1189 prevented TNF-alpha induced apoptosis. Both TNF-alpha and CPI-1189 treatment suppressed glial fibrillary acidic protein (GFAP) staining at the infusion site. TNF-alpha did not significantly affect the integrity of the blood-brain barrier, but CPI-1189 treatment increased blood-brain barrier integrity at the infusion site. No effect of TNF-alpha or CPI-1189 treatment was found on measures of oxidative stress. These results support TNF-alpha as a key agent for increasing apoptosis in AIDS dementia complex. Additionally, CPI-1189 treatment may protect against TNF-alpha induced apoptosis and astrogliosis in AIDS dementia complex. Lastly, the toxic effect of TNF-alpha and the protective effect of CPI-1189 may not be mediated primarily through manipulation of classic reactive oxygen species.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Butanes,
http://linkedlifedata.com/resource/pubmed/chemical/CPI 1189,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyl Radical,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Salicylates,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbituric Acid Reactive...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1355-0284
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
478-91
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11175320-AIDS Dementia Complex,
pubmed-meshheading:11175320-Administration, Oral,
pubmed-meshheading:11175320-Animals,
pubmed-meshheading:11175320-Antioxidants,
pubmed-meshheading:11175320-Apoptosis,
pubmed-meshheading:11175320-Astrocytes,
pubmed-meshheading:11175320-Basal Ganglia,
pubmed-meshheading:11175320-Blood-Brain Barrier,
pubmed-meshheading:11175320-Butanes,
pubmed-meshheading:11175320-Corpus Callosum,
pubmed-meshheading:11175320-Depression, Chemical,
pubmed-meshheading:11175320-Disease Models, Animal,
pubmed-meshheading:11175320-Drug Evaluation, Preclinical,
pubmed-meshheading:11175320-Glial Fibrillary Acidic Protein,
pubmed-meshheading:11175320-Gliosis,
pubmed-meshheading:11175320-Hydroxyl Radical,
pubmed-meshheading:11175320-Immunoglobulin G,
pubmed-meshheading:11175320-Injections, Intraventricular,
pubmed-meshheading:11175320-Lipid Peroxidation,
pubmed-meshheading:11175320-Male,
pubmed-meshheading:11175320-Neocortex,
pubmed-meshheading:11175320-Neuroprotective Agents,
pubmed-meshheading:11175320-Nitrogen Oxides,
pubmed-meshheading:11175320-Oxidative Stress,
pubmed-meshheading:11175320-Rats,
pubmed-meshheading:11175320-Rats, Sprague-Dawley,
pubmed-meshheading:11175320-Salicylates,
pubmed-meshheading:11175320-Septum Pellucidum,
pubmed-meshheading:11175320-Thiobarbituric Acid Reactive Substances,
pubmed-meshheading:11175320-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex.
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pubmed:affiliation |
Department of Psychology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA.
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pubmed:publicationType |
Journal Article
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