Source:http://linkedlifedata.com/resource/pubmed/id/11167437
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2001-2-22
|
| pubmed:abstractText |
Forty women undergoing elective Caesarean section under spinal anaesthesia using hyperbaric 0.5% bupivacaine were randomly allocated to receive either 0.5 mg or 1 mg intrathecal diamorphine. All women received diclofenac 100 mg at the end of surgery and morphine via a patient-controlled analgesia system. Oral analgesics were not used. Postoperative analgesia was more prolonged and more reliable in the 1-mg group. Mean time to first analgesia was 10.2 h in the 1-mg group and 6.9 h in the 0.5-mg group, and 45% in the 1-mg group used no morphine, compared with 10% in the 0.5-mg group. Mean morphine consumption over 24 h was 5.2 mg in the 1-mg group and 10.6 mg in the 0.5-mg group. Pain scores all tended to be lower in the 1-mg group but this was only significant at 4 h. There were no serious side-effects. Minor side-effects were common but well tolerated, and the incidence did not differ between the groups. If intrathecal diamorphine is used in combination with rectal diclofenac and without oral analgesia, then 1 mg provides superior analgesia to 0.5 mg without any worsening of the side-effects.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0003-2409
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
54-60
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:11167437-Administration, Rectal,
pubmed-meshheading:11167437-Adult,
pubmed-meshheading:11167437-Analgesia, Obstetrical,
pubmed-meshheading:11167437-Analgesia, Patient-Controlled,
pubmed-meshheading:11167437-Analgesics, Opioid,
pubmed-meshheading:11167437-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11167437-Cesarean Section,
pubmed-meshheading:11167437-Chi-Square Distribution,
pubmed-meshheading:11167437-Diclofenac,
pubmed-meshheading:11167437-Dose-Response Relationship, Drug,
pubmed-meshheading:11167437-Drug Therapy, Combination,
pubmed-meshheading:11167437-Female,
pubmed-meshheading:11167437-Heroin,
pubmed-meshheading:11167437-Humans,
pubmed-meshheading:11167437-Injections, Spinal,
pubmed-meshheading:11167437-Pain Measurement,
pubmed-meshheading:11167437-Pregnancy,
pubmed-meshheading:11167437-Statistics, Nonparametric,
pubmed-meshheading:11167437-Treatment Outcome
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
High-dose intrathecal diamorphine for analgesia after Caesarean section.
|
| pubmed:affiliation |
Consultant Anaesthetist, Kingston Hospital, Galsworthy Road, Kingston upon Thames KT2 7QB, UK.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|