|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
13-14
|
|
pubmed:dateCreated |
2001-2-22
|
|
pubmed:abstractText |
Neospora caninum infection is the major cause of bovine abortion. To develop a vaccine against N. caninum infection, recombinant vaccinia viruses carrying NcSRS2 and NcSAG1 genes (vv/Nc-p43 and vv/Nc-p36, respectively) were constructed and were tested in a mouse model. Vaccination of dams with vv/Nc-p43 appeared to confer effective protection against vertical transmission to offspring, though that with vv/Nc-p36 only provided partial protection. Moreover, the vv/Nc-p43 vaccination provoked cellular immune responses and antibody production against N. caninum. In conclusion, it is expected that vv/Nc-p43 can be used as an effective live vaccine to prevent vertical transmission of N. caninum in natural hosts.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0264-410X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1710-6
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:11166895-Animals,
pubmed-meshheading:11166895-Antibodies, Monoclonal,
pubmed-meshheading:11166895-Antibodies, Protozoan,
pubmed-meshheading:11166895-Antibody Specificity,
pubmed-meshheading:11166895-Antigens, Protozoan,
pubmed-meshheading:11166895-Coccidiosis,
pubmed-meshheading:11166895-Concanavalin A,
pubmed-meshheading:11166895-DNA, Protozoan,
pubmed-meshheading:11166895-Female,
pubmed-meshheading:11166895-Genes, Protozoan,
pubmed-meshheading:11166895-Infectious Disease Transmission, Vertical,
pubmed-meshheading:11166895-Litter Size,
pubmed-meshheading:11166895-Male,
pubmed-meshheading:11166895-Mice,
pubmed-meshheading:11166895-Mice, Inbred BALB C,
pubmed-meshheading:11166895-Neospora,
pubmed-meshheading:11166895-Pregnancy,
pubmed-meshheading:11166895-Protozoan Vaccines,
pubmed-meshheading:11166895-Spleen,
pubmed-meshheading:11166895-Survival Rate,
pubmed-meshheading:11166895-T-Lymphocytes,
pubmed-meshheading:11166895-Vaccination,
pubmed-meshheading:11166895-Vaccines, Synthetic,
pubmed-meshheading:11166895-Vaccinia virus
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Prevention of vertical transmission of Neospora caninum in BALB/c mice by recombinant vaccinia virus carrying NcSRS2 gene.
|
|
pubmed:affiliation |
The National Research Center for Protozoan Diseases, Obihiro University, Nishi 2-11, Inadacho, Obihiro, 080-8555, Hokkaido, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
