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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Systemic lupus erythematosus is an autoimmune disease characterized by the presence of autoantibodies. One of the unique targets of the immune system in systemic lupus erythematosus is Sm, a ribonucleoprotein present in all cells. To understand the regulation of B cells specific to the Sm Ag in normal mice, we have generated an Ig H chain transgenic mouse (2-12H Tg). 2-12H Tg mice produce B cells specific for the Sm that remain tolerant due to ignorance. We demonstrate here that anti-Sm B cells of 2-12H Tg mice can differentiate into Sm-specific peritoneal B-1 cells that remain tolerant. Differentiation to B-1 and tolerance are governed by the strength of B cell receptor signaling, since manipulations of the B cell receptor coreceptors CD19 and CD22 affect anti-Sm B cell differentiation and autoantibody production. These results suggest a differentiation scheme in which peripheral ignorance to Sm is maintained in mice by the differentiation of anti-Sm B cells to B-1 cells that have increased activation thresholds.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD19,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD22,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Cd22 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins, Small Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Snrpb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/snRNP Core Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2412-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11160300-Animals,
pubmed-meshheading:11160300-Antigens, CD,
pubmed-meshheading:11160300-Antigens, CD19,
pubmed-meshheading:11160300-Antigens, CD22,
pubmed-meshheading:11160300-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:11160300-Autoantibodies,
pubmed-meshheading:11160300-Autoantigens,
pubmed-meshheading:11160300-B-Lymphocyte Subsets,
pubmed-meshheading:11160300-Cell Adhesion Molecules,
pubmed-meshheading:11160300-Cell Differentiation,
pubmed-meshheading:11160300-Immune Tolerance,
pubmed-meshheading:11160300-Lectins,
pubmed-meshheading:11160300-Lupus Erythematosus, Systemic,
pubmed-meshheading:11160300-Mice,
pubmed-meshheading:11160300-Mice, Inbred MRL lpr,
pubmed-meshheading:11160300-Mice, Knockout,
pubmed-meshheading:11160300-Mice, Transgenic,
pubmed-meshheading:11160300-Peritoneum,
pubmed-meshheading:11160300-Receptors, Antigen, B-Cell,
pubmed-meshheading:11160300-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:11160300-Signal Transduction,
pubmed-meshheading:11160300-Spleen,
pubmed-meshheading:11160300-snRNP Core Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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