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rdf:type |
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lifeskim:mentions |
umls-concept:C0015385,
umls-concept:C0017262,
umls-concept:C0040300,
umls-concept:C0205263,
umls-concept:C0376449,
umls-concept:C0444498,
umls-concept:C0851285,
umls-concept:C1160421,
umls-concept:C1171362,
umls-concept:C1333539,
umls-concept:C1515670,
umls-concept:C1533691
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-16
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pubmed:abstractText |
Teneurin-2 is a member of a novel family of transmembrane proteins characterized to date in fish, birds, mammals, and Drosophila (e.g., the pair-rule gene product Ten-m). We have shown that teneurin-2 is expressed by neurons in the developing avian visual system in a pattern complementary to the expression of teneurin-1 and that recombinant teneurin-2 induces morphologic changes in neuronal cells in culture (Rubin et al., 1999). Here we have used cRNA probes to two newly identified splice variants and a teneurin-2-specific antibody to determine whether teneurin-2 is also expressed outside the nervous system. Both reverse transcriptase-polymerase chain reaction and in situ hybridization indicate that the three splice variants known so far are coexpressed at sites of pattern formation during development. Teneurin-2 mRNAs and protein are found in the developing limbs, somites, and craniofacial mesenchyme. In addition to expression of teneurin-2 by the apical ectodermal ridge, teneurin-2 transcripts also appear transiently at sites of tendon development. Teneurin-2 expression patterns were strikingly similar to those of fibroblast growth factor 8 (FGF8). In agreement with the overlapping expression pattern, FGF8-coated beads implanted into chicken limb buds induced the ectopic expression of teneurin-2 and soluble FGF8 induced teneurin-2 in limb explant cultures. Thus, teneurin-2 could act downstream of FGF8 during morphogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 8,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fibroblast Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/teneurin-2 protein, chicken
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1058-8388
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
220
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-39
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11146505-Alternative Splicing,
pubmed-meshheading:11146505-Amino Acid Sequence,
pubmed-meshheading:11146505-Animals,
pubmed-meshheading:11146505-Avian Proteins,
pubmed-meshheading:11146505-Chick Embryo,
pubmed-meshheading:11146505-Cloning, Molecular,
pubmed-meshheading:11146505-Embryo, Nonmammalian,
pubmed-meshheading:11146505-Extremities,
pubmed-meshheading:11146505-Fibroblast Growth Factor 8,
pubmed-meshheading:11146505-Fibroblast Growth Factors,
pubmed-meshheading:11146505-Gene Library,
pubmed-meshheading:11146505-Immunohistochemistry,
pubmed-meshheading:11146505-In Situ Hybridization,
pubmed-meshheading:11146505-Limb Buds,
pubmed-meshheading:11146505-Membrane Proteins,
pubmed-meshheading:11146505-Mesoderm,
pubmed-meshheading:11146505-Molecular Sequence Data,
pubmed-meshheading:11146505-Nerve Tissue Proteins,
pubmed-meshheading:11146505-Nervous System,
pubmed-meshheading:11146505-Organ Culture Techniques,
pubmed-meshheading:11146505-RNA, Complementary,
pubmed-meshheading:11146505-RNA, Messenger,
pubmed-meshheading:11146505-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:11146505-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11146505-Sequence Homology, Amino Acid,
pubmed-meshheading:11146505-Signal Transduction,
pubmed-meshheading:11146505-Somites,
pubmed-meshheading:11146505-Tendons,
pubmed-meshheading:11146505-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Teneurin-2 is expressed in tissues that regulate limb and somite pattern formation and is induced in vitro and in situ by FGF8.
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pubmed:affiliation |
Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, California.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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