Source:http://linkedlifedata.com/resource/pubmed/id/11121190
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2000-12-21
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| pubmed:abstractText |
Tumor necrosis factor (TNF), a proinflammatory cytokine, may be involved in the pathogenesis of Alzheimer disease (AD) based on observations that senile plaques have been found to upregulate proinflammatory cytokines. Additionally, nonsteroidal anti-inflammatory drugs have been found to delay and prevent the onset of AD. A collaborative genome-wide scan for AD genes in 266 late-onset families implicated a 20 centimorgan region at chromosome 6p21.3 that includes the TNF gene. Three TNF polymorphisms, a -308 TNF promoter polymorphism, whose TNF2 allele is associated with autoimmune inflammatory diseases and strong transcriptional activity, the -238 TNF promoter polymorphism, and the microsatellite TNFa, whose 2 allele is associated with a high TNF secretion, were typed in 145 families consisting of 562 affected and unaffected siblings. These polymorphisms formed a haplotype, 2-1-2, respectively, that was significantly associated with AD (P = 0.005) using the sibling disequilibrium test. Singly, the TNFa2 allele was also significantly associated (P = 0.04) with AD in these 145 families. This TNF association with AD lends further support for an inflammatory process in the pathogenesis of AD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:823-830, 2000.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0148-7299
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| pubmed:author |
pubmed-author:ActonR TRT,
pubmed-author:AlbertM SMS,
pubmed-author:BassettS SSS,
pubmed-author:BlackerDD,
pubmed-author:CampbellR DRD,
pubmed-author:CollinsJ SJS,
pubmed-author:GoR CRC,
pubmed-author:HarrellL ELE,
pubmed-author:McInnisM GMG,
pubmed-author:PerryR TRT,
pubmed-author:TanziR ERE,
pubmed-author:WatsonBBJr
|
| pubmed:copyrightInfo |
Copyright 2000 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
96
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
823-30
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11121190-Age of Onset,
pubmed-meshheading:11121190-Alleles,
pubmed-meshheading:11121190-Alzheimer Disease,
pubmed-meshheading:11121190-Chromosome Mapping,
pubmed-meshheading:11121190-Chromosomes, Human, Pair 6,
pubmed-meshheading:11121190-DNA,
pubmed-meshheading:11121190-Family Health,
pubmed-meshheading:11121190-Gene Frequency,
pubmed-meshheading:11121190-Genotype,
pubmed-meshheading:11121190-Haplotypes,
pubmed-meshheading:11121190-Humans,
pubmed-meshheading:11121190-Lod Score,
pubmed-meshheading:11121190-Microsatellite Repeats,
pubmed-meshheading:11121190-National Institute of Mental Health (U.S.),
pubmed-meshheading:11121190-Nuclear Family,
pubmed-meshheading:11121190-Polymorphism, Genetic,
pubmed-meshheading:11121190-Promoter Regions, Genetic,
pubmed-meshheading:11121190-Software,
pubmed-meshheading:11121190-Statistics, Nonparametric,
pubmed-meshheading:11121190-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11121190-United States
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative.
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| pubmed:affiliation |
Department of Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, Alabama 35294-0022, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Multicenter Study
|