Linked Life Data

11117293

Source:http://linkedlifedata.com/resource/pubmed/id/11117293

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-12-14
pubmed:abstractText
Osteonecrosis of the femoral head often results in secondary osteoarthritis of the hip joint; however, the pathologic processes underlying the destruction of articular cartilage are not fully understood. Molecular markers in the hip joint fluids were measured to examine the changes in turnover of cartilage and other joint tissues. Marker data were related to clinical, radiological, and histopathological changes in the articular cartilage of the hip. Forty-five patients (median age: 43 years) were studied. The median time between the onset of symptoms and sampling of hip synovial fluid was 6 months. Aggrecan fragments, C-propeptide of type-II collagen, matrix metalloproteinase-3, and tissue inhibitor of metalloproteinases-1 levels in joint fluid were determined by immunoassay. Osteonecrosis of the femoral head was graded by radiology as minimal collapse of the femoral head (stage 2: 26 patients), severe collapse (stage 3: 15 patients), or severe collapse with osteoarthritis (stage 4: four patients). Histological changes of the articular cartilage, consistent with early-stage osteoarthritis, were evident at stage 3 and were more advanced at stage 4. The average concentrations of proteoglycan fragments and C-propeptide of type-II collagen were 207 (SD 182) microg/ml and 19.6 (SD 19.3) ng/ml, respectively. The average concentrations of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 were 177 (SD 291) nM and 23.0 (SD 9.9) nM, respectively. Measurable levels for all markers assayed were noted in the earliest stage of the disease, only a few months after the onset of symptoms and well before the appearance of radiological changes. Levels of matrix metalloproteinase-3 and molar ratios of matrix metalloproteinase-3/tissue inhibitor of metalloproteinases-1 were higher in early stage disease than in later stage disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0736-0266
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
728-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11117293-Adult, pubmed-meshheading:11117293-Aged, pubmed-meshheading:11117293-Aggrecans, pubmed-meshheading:11117293-Biological Markers, pubmed-meshheading:11117293-Calcium-Binding Proteins, pubmed-meshheading:11117293-Cartilage, Articular, pubmed-meshheading:11117293-Collagen, pubmed-meshheading:11117293-Collagen Type II, pubmed-meshheading:11117293-Extracellular Matrix Proteins, pubmed-meshheading:11117293-Female, pubmed-meshheading:11117293-Femur Head Necrosis, pubmed-meshheading:11117293-Hip Joint, pubmed-meshheading:11117293-Humans, pubmed-meshheading:11117293-Immunoassay, pubmed-meshheading:11117293-Lectins, C-Type, pubmed-meshheading:11117293-Male, pubmed-meshheading:11117293-Matrix Metalloproteinase 3, pubmed-meshheading:11117293-Middle Aged, pubmed-meshheading:11117293-Osteoarthritis, pubmed-meshheading:11117293-Proteoglycans, pubmed-meshheading:11117293-Synovial Fluid, pubmed-meshheading:11117293-Tissue Inhibitor of Metalloproteinase-1
pubmed:year
2000
pubmed:articleTitle
Markers of joint tissue turnover in joint fluids from hips with osteonecrosis of the femoral head.
pubmed:affiliation
Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. jingushi@ortho.med.kyushu-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't