| pubmed-article:11114729 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C0699790 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C0140080 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C0021666 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:11114729 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11114729 | pubmed:issue | 48 | lld:pubmed |
| pubmed-article:11114729 | pubmed:dateCreated | 2000-12-20 | lld:pubmed |
| pubmed-article:11114729 | pubmed:abstractText | Nonsteroidal anti-inflammatory drugs reduce the risk of colon cancer and this effect is mediated in part through inhibition of type 2 prostaglandin endoperoxide synthase/ cyclo-oxygenase (COX-2). In the present study, we demonstrate that COX-2 expression and PGE2 synthesis are up-regulated by an IGF-II/IGF-I receptor autocrine pathway in Caco-2 colon carcinoma cells. COX-2 mRNA and PGE2 levels are higher in proliferating cells compared with post-confluent differentiated cells and in cells that constitutively overexpress IGF-II. Up-regulation of COX-2 expression by IGF-II is mediated through activation of IGF-I receptor because: (i) treatment of Caco-2 cells with a blocking antibody to the IGF-I receptor inhibits COX-2 mRNA expression; (ii) transfection of Caco-2 cells with a dominant negative IGF-I receptor reduces COX-2 expression and activity. Also, the blockade of the PI3-kinase, that mediates the proliferative effect of IGF-I receptor in Caco-2 cells, inhibits IGF-II-dependent COX-2 up-regulation and PGE2 synthesis. Moreover, COX-2 expression and activity inversely correlate with the increase of apoptosis in parental, IGF-II and dominant-negative IGF-I receptor transfected cells. This study suggests that induction of proliferation and tumor progression of colon cancer cells by the IGF-II/IGF-I receptor pathway may depend on the activation of COX-2-related events. | lld:pubmed |
| pubmed-article:11114729 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11114729 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11114729 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11114729 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11114729 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:11114729 | pubmed:author | pubmed-author:AcquavivaA... | lld:pubmed |
| pubmed-article:11114729 | pubmed:author | pubmed-author:ApicellaAA | lld:pubmed |
| pubmed-article:11114729 | pubmed:author | pubmed-author:MemoliAA | lld:pubmed |
| pubmed-article:11114729 | pubmed:author | pubmed-author:di PalmaAA | lld:pubmed |
| pubmed-article:11114729 | pubmed:author | pubmed-author:ZarrilliRR | lld:pubmed |
| pubmed-article:11114729 | pubmed:author | pubmed-author:TuccilloCC | lld:pubmed |
| pubmed-article:11114729 | pubmed:author | pubmed-author:RicchiPP | lld:pubmed |
| pubmed-article:11114729 | pubmed:author | pubmed-author:Di PopoloAA | lld:pubmed |
| pubmed-article:11114729 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11114729 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:11114729 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:11114729 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11114729 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11114729 | pubmed:pagination | 5517-24 | lld:pubmed |
| pubmed-article:11114729 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11114729 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11114729 | pubmed:articleTitle | IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells. | lld:pubmed |
| pubmed-article:11114729 | pubmed:affiliation | Dipartimento di Biologia e Patologia Cellulare e Molecolare, L Califano, Centro di Endocrinologia ed Oncologia Sperimentale G. Salvatore del Consiglio Nazionale delle Ricerche, Università Federico II, Napoli, Italy. | lld:pubmed |
| pubmed-article:11114729 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11114729 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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