|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-2-14
|
|
pubmed:abstractText |
Runt and Lozenge (LZ) are members of the Runt domain family of transcriptional regulators and control a large number of developmental processes in Drosophila. Runt is a pair-rule gene, and is part of the network of genes that control pattern formation in the embryo. In the central nervous system, Runt function is necessary for the development of a subset of neurons. Runt is also a key regulator of sex determination, and directly controls Sex-lethal, a master gene that determines sex of the animal and controls dosage compensation. The LZ protein also participates in several key processes. LZ controls pre-patterning and cell-fate choices in the development of the visual system by regulating the expression of several fate-specifying transcription factors, and works in conjunction with general signaling pathways. LZ function is also required in hematopoiesis for the specification of a Drosophila blood cell lineage.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1084-9521
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
327-36
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11105896-Animals,
pubmed-meshheading:11105896-Body Patterning,
pubmed-meshheading:11105896-DNA-Binding Proteins,
pubmed-meshheading:11105896-Drosophila Proteins,
pubmed-meshheading:11105896-Drosophila melanogaster,
pubmed-meshheading:11105896-Eye,
pubmed-meshheading:11105896-Female,
pubmed-meshheading:11105896-Gene Expression Regulation, Developmental,
pubmed-meshheading:11105896-Male,
pubmed-meshheading:11105896-Nuclear Proteins,
pubmed-meshheading:11105896-Sex Determination Processes,
pubmed-meshheading:11105896-Transcription, Genetic,
pubmed-meshheading:11105896-Transcription Factors
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Runt and Lozenge function in Drosophila development.
|
|
pubmed:affiliation |
Department of Biological Chemistry, Molecular Biology Institute, University of California at Los Angeles, 90095, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|
