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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-11-21
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pubmed:abstractText |
Whole-cell recording in the superficial layers of the developing superior colliculus (sSC) reveals a large drop in NMDA receptor (NMDAR) current decay time synchronized across all neurons and occurring consistently between P10 and P11. We show that blocking the Ca2+/calmodulin-dependent phosphatase calcineurin (CaN) in the postsynaptic neuron can abolish this drop. The regulation is induced prematurely by 1-2 hr of electrical stimulation in P10 collicular slices only if CaN and NMDAR currents can be activated in the neuron. These data suggest that a long-lasting, CaN-mediated control of NMDAR kinetics is rapidly initiated by heightened activity of the NMDAR itself and demonstrate a novel developmental and tonic function of CaN that can play an important role in modulating the plasticity of the developing CNS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/NR1 NMDA receptor,
http://linkedlifedata.com/resource/pubmed/chemical/NR2A NMDA receptor,
http://linkedlifedata.com/resource/pubmed/chemical/NR2B NMDA receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/ifenprodil
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-14
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11086987-Action Potentials,
pubmed-meshheading:11086987-Calcineurin,
pubmed-meshheading:11086987-Dose-Response Relationship, Drug,
pubmed-meshheading:11086987-Down-Regulation,
pubmed-meshheading:11086987-Electric Stimulation,
pubmed-meshheading:11086987-Enzyme Inhibitors,
pubmed-meshheading:11086987-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11086987-Excitatory Postsynaptic Potentials,
pubmed-meshheading:11086987-Gene Expression Regulation, Developmental,
pubmed-meshheading:11086987-Ion Transport,
pubmed-meshheading:11086987-Neuronal Plasticity,
pubmed-meshheading:11086987-Neurons,
pubmed-meshheading:11086987-Patch-Clamp Techniques,
pubmed-meshheading:11086987-Piperidines,
pubmed-meshheading:11086987-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:11086987-Superior Colliculi,
pubmed-meshheading:11086987-Synapses,
pubmed-meshheading:11086987-Tacrolimus
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pubmed:year |
2000
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pubmed:articleTitle |
Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents.
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pubmed:affiliation |
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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