Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1976-3-20
pubmed:abstractText
Peptic secretion was studied in fasting anaesthetized cats in which the pylorus and common bile duct had been occluded to prevent the release of duodenal hormones which might stimulate or inhibit gastric secretion. Dilute acid was instilled into the stomach at intervals to aid recovery of gastric secretion and to preserve peptic activity. 2. Caerulein, histamine and N-methyl histamine did not increase the output of pepsin when given on their own. Desulphated caerulein was a weak peptic stimulant. 3. Two C.H.R. u./kg per hour secretin initiated pancreatic secretion, the volume of which increased progressively as the dose was increased by stages to 32 C.H.R. u./kg per hour. 4. Four C.H.R. u./kg per hour secretin did not increase the output of pepsin. Peptic secretion was stimulated by 8 C.H.R. u./kg per hour. A maximal output of approximately 2000 u. pepsin/15 min was obtained when 16 C.H.R. u./kg per hour was infused. 5. When each acid stimulant was infused along with 4 C.H.R. u./kg per hour secretin the output of pepsin increased significantly. The peak output, which usually occurred between 15 and 30 min after stimulation, did not exceed 1000 u. pepsin/15 min. 6. The proposed explanation for the potentiation of the peptic response when an acid stimulant is infused along with a dose of secretin, in itself below the threshold of peptic stimulation, is that each acid stimulant increases gastric mucosal blood flow, approximately doubling the effective concentration of secretin delivered to the peptic cell.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-13131242, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-13662018, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-14127513, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-16748230, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-16993803, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-16995184, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4551008, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4561614, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4637984, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4879882, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4883929, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4885441, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4886027, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4891704, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4895184, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4901147, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4904949, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4910993, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4922127, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4928882, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-4952746, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-5157592, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-5320025, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-5560711, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-5636998, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-5683173, http://linkedlifedata.com/resource/pubmed/commentcorrection/1107522-5922945
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
791-801
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
The influence of secretin on the secretion of pepsin in response to acid stimulants in the anaesthetized cat.
pubmed:publicationType
Journal Article