| pubmed-article:11067941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C0384648 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C1705593 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C0225335 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C0282553 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C1332652 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C0751982 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C0442120 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:11067941 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:11067941 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11067941 | pubmed:dateCreated | 2000-11-21 | lld:pubmed |
| pubmed-article:11067941 | pubmed:abstractText | IL-17 is a newly discovered cytokine implicated in the regulation of hemopoiesis and inflammation. Because IL-17 production is restricted to activated T lymphocytes, the effects exerted by IL-17 may help one to understand the contribution of T cells to the inflammatory response. We investigated the role of IL-17 in leukocyte recruitment into the peritoneal cavity. Leukocyte infiltration in vivo was assessed in BALB/Cj mice. Effects of IL-17 on chemokine generation in vitro were examined in human peritoneal mesothelial cells (HPMC). Administration of IL-17 i.p. resulted in a selective recruitment of neutrophils into the peritoneum and increased levels of KC chemokine (murine homologue of human growth-related oncogene alpha (GROalpha). Pretreatment with anti-KC Ab significantly reduced the IL-17-driven neutrophil accumulation. Primary cultures of HPMC expressed IL-17 receptor mRNA. Exposure of HPMC to IL-17 led to a dose- and time-dependent induction of GROalpha mRNA and protein. Combination of IL-17 together with TNF-alpha resulted in an increased stability of GROalpha mRNA and synergistic release of GROalpha protein. Anti-IL-17 Ab blocked the effects of IL-17 in vitro and in vivo. IL-17 is capable of selectively recruiting neutrophils into the peritoneal cavity via the release of neutrophil-specific chemokines from the peritoneal mesothelium. | lld:pubmed |
| pubmed-article:11067941 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11067941 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11067941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11067941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11067941 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11067941 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:HAAKE DED | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:BreborowiczAA | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:FreiUU | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:JörresAA | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:FriessHH | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:WisniewskaJJ | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:WitowskiJJ | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:ScheurerEE | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:PawlaczykKK | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:PolubinskaAA | lld:pubmed |
| pubmed-article:11067941 | pubmed:author | pubmed-author:Kuzlan-Pawlac... | lld:pubmed |
| pubmed-article:11067941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11067941 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11067941 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:11067941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11067941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11067941 | pubmed:pagination | 5814-21 | lld:pubmed |
| pubmed-article:11067941 | pubmed:dateRevised | 2008-5-6 | lld:pubmed |
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| pubmed-article:11067941 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11067941 | pubmed:articleTitle | IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells. | lld:pubmed |
| pubmed-article:11067941 | pubmed:affiliation | Department of Pathophysiology, University Medical School, Poznan, Poland. | lld:pubmed |
| pubmed-article:11067941 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11067941 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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