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rdf:type |
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lifeskim:mentions |
umls-concept:C0030685,
umls-concept:C0225335,
umls-concept:C0282553,
umls-concept:C0384648,
umls-concept:C0391871,
umls-concept:C0442120,
umls-concept:C0680255,
umls-concept:C0751982,
umls-concept:C1283071,
umls-concept:C1332652,
umls-concept:C1705593,
umls-concept:C1963578
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pubmed:issue |
10
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pubmed:dateCreated |
2000-11-21
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pubmed:abstractText |
IL-17 is a newly discovered cytokine implicated in the regulation of hemopoiesis and inflammation. Because IL-17 production is restricted to activated T lymphocytes, the effects exerted by IL-17 may help one to understand the contribution of T cells to the inflammatory response. We investigated the role of IL-17 in leukocyte recruitment into the peritoneal cavity. Leukocyte infiltration in vivo was assessed in BALB/Cj mice. Effects of IL-17 on chemokine generation in vitro were examined in human peritoneal mesothelial cells (HPMC). Administration of IL-17 i.p. resulted in a selective recruitment of neutrophils into the peritoneum and increased levels of KC chemokine (murine homologue of human growth-related oncogene alpha (GROalpha). Pretreatment with anti-KC Ab significantly reduced the IL-17-driven neutrophil accumulation. Primary cultures of HPMC expressed IL-17 receptor mRNA. Exposure of HPMC to IL-17 led to a dose- and time-dependent induction of GROalpha mRNA and protein. Combination of IL-17 together with TNF-alpha resulted in an increased stability of GROalpha mRNA and synergistic release of GROalpha protein. Anti-IL-17 Ab blocked the effects of IL-17 in vitro and in vivo. IL-17 is capable of selectively recruiting neutrophils into the peritoneal cavity via the release of neutrophil-specific chemokines from the peritoneal mesothelium.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Dactinomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/IL17RA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Il17r protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immune Sera,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BreborowiczAA,
pubmed-author:FreiUU,
pubmed-author:FriessHH,
pubmed-author:HAAKE DED,
pubmed-author:JörresAA,
pubmed-author:Kuzlan-PawlaczykMM,
pubmed-author:PawlaczykKK,
pubmed-author:PolubinskaAA,
pubmed-author:ScheurerEE,
pubmed-author:WisniewskaJJ,
pubmed-author:WitowskiJJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5814-21
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pubmed:dateRevised |
2008-5-6
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pubmed:meshHeading |
pubmed-meshheading:11067941-Animals,
pubmed-meshheading:11067941-Cells, Cultured,
pubmed-meshheading:11067941-Chemokine CXCL1,
pubmed-meshheading:11067941-Chemokines, CXC,
pubmed-meshheading:11067941-Chemotactic Factors,
pubmed-meshheading:11067941-Cycloheximide,
pubmed-meshheading:11067941-Dactinomycin,
pubmed-meshheading:11067941-Epithelium,
pubmed-meshheading:11067941-Growth Substances,
pubmed-meshheading:11067941-Humans,
pubmed-meshheading:11067941-Immune Sera,
pubmed-meshheading:11067941-Injections, Intraperitoneal,
pubmed-meshheading:11067941-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11067941-Interleukin-17,
pubmed-meshheading:11067941-Male,
pubmed-meshheading:11067941-Mice,
pubmed-meshheading:11067941-Mice, Inbred BALB C,
pubmed-meshheading:11067941-Neutrophil Infiltration,
pubmed-meshheading:11067941-Peritoneum,
pubmed-meshheading:11067941-Protein Biosynthesis,
pubmed-meshheading:11067941-RNA, Messenger,
pubmed-meshheading:11067941-Receptors, Interleukin,
pubmed-meshheading:11067941-Receptors, Interleukin-17,
pubmed-meshheading:11067941-Recombinant Proteins,
pubmed-meshheading:11067941-Transcription, Genetic,
pubmed-meshheading:11067941-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells.
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pubmed:affiliation |
Department of Pathophysiology, University Medical School, Poznan, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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