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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-10-27
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pubmed:abstractText |
Osteoprotegerin-ligand (OPGL) is a key osteoclast differentiation/activation factor essential for bone remodeling. We report that mice lacking OPGL or its receptor RANK fail to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Transplantation and OPGL-rescue experiments in opgl-/- and rank-/- pregnant females showed that OPGL acts directly on RANK-expressing mammary epithelial cells. The effects of OPGL are autonomous to epithelial cells. The mammary gland defect in female opgl-/- mice is characterized by enhanced apoptosis and failures in proliferation and PKB activation in lobulo-alveolar buds that can be reversed by recombinant OPGL treatment. These data provide a novel paradigm in mammary gland development and an evolutionary rationale for hormonal regulation and gender bias of osteoporosis in females.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadal Steroid Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Osteoprotegerin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:BoyleW JWJ,
pubmed-author:ElliottRR,
pubmed-author:FataJ EJE,
pubmed-author:Irie-SasakiJJ,
pubmed-author:KhokhaRR,
pubmed-author:KongY YYY,
pubmed-author:LaceyD LDL,
pubmed-author:MooreheadR ARA,
pubmed-author:OOIS KSK,
pubmed-author:PenningerJ MJM,
pubmed-author:SasakiTT,
pubmed-author:ScullySS,
pubmed-author:VouraE BEB
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-50
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11051546-Animals,
pubmed-meshheading:11051546-Bone Remodeling,
pubmed-meshheading:11051546-Carrier Proteins,
pubmed-meshheading:11051546-Cell Division,
pubmed-meshheading:11051546-Cell Survival,
pubmed-meshheading:11051546-Epithelial Cells,
pubmed-meshheading:11051546-Female,
pubmed-meshheading:11051546-Glycoproteins,
pubmed-meshheading:11051546-Gonadal Steroid Hormones,
pubmed-meshheading:11051546-Mammary Glands, Animal,
pubmed-meshheading:11051546-Membrane Glycoproteins,
pubmed-meshheading:11051546-Mice,
pubmed-meshheading:11051546-Mice, Knockout,
pubmed-meshheading:11051546-Osteoporosis,
pubmed-meshheading:11051546-Osteoprotegerin,
pubmed-meshheading:11051546-Phenotype,
pubmed-meshheading:11051546-Phosphorylation,
pubmed-meshheading:11051546-Pregnancy,
pubmed-meshheading:11051546-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11051546-Proto-Oncogene Proteins,
pubmed-meshheading:11051546-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:11051546-RANK Ligand,
pubmed-meshheading:11051546-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:11051546-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:11051546-Receptors, Tumor Necrosis Factor
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pubmed:year |
2000
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pubmed:articleTitle |
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
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pubmed:affiliation |
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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