Linked Life Data

11027837

Source:http://linkedlifedata.com/resource/pubmed/id/11027837

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2000-11-15
pubmed:abstractText
[corrected] The use of allogeneic cord blood (CB) products as a source of cellular support for patients receiving high-dose chemotherapy has been limited primarily to smaller children due to the low numbers of cells in a CB unit. Ex vivo expansion of CB cells has been proposed as a method to increase the number of cells available for transplantation. Following high-dose chemotherapy administration, we transplanted adult patients with CB expanded in static culture for 10 days, in DM containing stem cell factor (SCF), granulocyte colony-stimulating factor (G-CSF), and megakaryocyte growth and development factor (MGDF). Patients achieved neutrophil engraftment in a median of 26 days (range 15 to 45). In an attempt to hasten the time to neutrophil engraftment, we developed a two-step culture system that results in increased expansion of total nucleated cells and further maturation of neutrophil precursors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1181-6
pubmed:dateRevised
2008-7-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Increased expansion and differentiation of cord blood products using a two-step expansion culture.
pubmed:affiliation
Experimental Hematology Laboratory, BMT Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA. ian.mcniece@uchsc.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't