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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-11-8
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pubmed:abstractText |
The Drosophila rhomboid (rho) gene participates in localized activation of EGF-receptor signaling in various developmental settings. The Rhomboid protein has been proposed to promote presentation and/or processing of the membrane-bound Spitz (mSpi) EGF-related ligand to generate an active diffusible form of the ligand. Here, we report on a new rhomboid-related gene identified by sequence similarity searching that we have named brother of rhomboid (brho). In contrast to rho, which is expressed in complex patterns during many stages of development, brho appears to be expressed only during oogenesis. brho transcripts are present in early oocytes and abut posterior follicle cells which exhibit high levels of MAPK activation. brho, like rho, collaborates with Star to promote signaling through the EGF-R/MAPK pathway, and genetic evidence indicates that Brho can activate both the mSpi and the Grk precursor EGF ligands in the wing. We propose that endogenous brho may activate the oocyte-specific Gurken ligand and thereby participate in defining posterior cell fates in the early follicular epithelium.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Rho protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/gurken protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/rho-2 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/spi protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/steroidogenic acute regulatory...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0012-1606
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
226
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
255-66
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11023685-Amino Acid Sequence,
pubmed-meshheading:11023685-Animals,
pubmed-meshheading:11023685-Drosophila Proteins,
pubmed-meshheading:11023685-Drosophila melanogaster,
pubmed-meshheading:11023685-Embryo, Nonmammalian,
pubmed-meshheading:11023685-Enzyme Activation,
pubmed-meshheading:11023685-Epidermal Growth Factor,
pubmed-meshheading:11023685-Female,
pubmed-meshheading:11023685-Gene Expression Regulation, Developmental,
pubmed-meshheading:11023685-Insect Proteins,
pubmed-meshheading:11023685-Larva,
pubmed-meshheading:11023685-MAP Kinase Signaling System,
pubmed-meshheading:11023685-Membrane Proteins,
pubmed-meshheading:11023685-Molecular Sequence Data,
pubmed-meshheading:11023685-Multigene Family,
pubmed-meshheading:11023685-Oocytes,
pubmed-meshheading:11023685-Oogenesis,
pubmed-meshheading:11023685-Ovarian Follicle,
pubmed-meshheading:11023685-Phosphoproteins,
pubmed-meshheading:11023685-Phylogeny,
pubmed-meshheading:11023685-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11023685-Sequence Alignment,
pubmed-meshheading:11023685-Sequence Homology, Amino Acid,
pubmed-meshheading:11023685-Transcription, Genetic,
pubmed-meshheading:11023685-Transforming Growth Factor alpha,
pubmed-meshheading:11023685-Transforming Growth Factors,
pubmed-meshheading:11023685-Wing
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pubmed:year |
2000
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pubmed:articleTitle |
brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling.
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pubmed:affiliation |
Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0349, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
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