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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-10-25
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pubmed:abstractText |
Semaphorins comprise a large family of phylogenetically conserved secreted and transmembrane glycoproteins, many of which have been implicated in repulsive axon guidance events. The transmembrane semaphorin Sema-1a in Drosophila is expressed on motor axons and is required for the generation of neuromuscular connectivity. Sema-1a can function as an axonal repellent and mediates motor axon defasciculation. Here, by manipulating the levels of Sema-1a and the cell adhesion molecules fasciclin II (Fas II) and connectin (Conn) on motor axons, we provide further evidence that Sema-1a mediates axonal defasciculation events by acting as an axonally localized repellent and that correct motor axon guidance results from a balance between attractive and repulsive guidance cues expressed on motor neurons.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-10027283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-10049528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-10051670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-10202543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-10679438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-10729344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-1505024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-1913818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-3058545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-7877688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-7917288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-7917289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-7946345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-7958857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-8060618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-8175919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-8223268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-8240822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-8513498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-8893022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-8978609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-9108360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-9321691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-9321710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-9374410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-9491983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11014819-9875845
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
723-31
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11014819-Animals,
pubmed-meshheading:11014819-Animals, Genetically Modified,
pubmed-meshheading:11014819-Axons,
pubmed-meshheading:11014819-Cell Adhesion Molecules,
pubmed-meshheading:11014819-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:11014819-Crosses, Genetic,
pubmed-meshheading:11014819-Drosophila melanogaster,
pubmed-meshheading:11014819-Fasciculation,
pubmed-meshheading:11014819-Female,
pubmed-meshheading:11014819-Genotype,
pubmed-meshheading:11014819-Glycoproteins,
pubmed-meshheading:11014819-Male,
pubmed-meshheading:11014819-Muscle Proteins,
pubmed-meshheading:11014819-Nerve Growth Factors,
pubmed-meshheading:11014819-Protein Kinases,
pubmed-meshheading:11014819-Semaphorin-3A
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pubmed:year |
2000
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pubmed:articleTitle |
Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin II and connectin to regulate axon fasciculation in Drosophila.
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pubmed:affiliation |
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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