| pubmed-article:11006320 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0042133 | lld:lifeskim |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0027088 | lld:lifeskim |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0458083 | lld:lifeskim |
| pubmed-article:11006320 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:11006320 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11006320 | pubmed:dateCreated | 2000-10-18 | lld:pubmed |
| pubmed-article:11006320 | pubmed:abstractText | The expression of insulin-like growth factor-I (IGF-I) was measured at the mRNA and protein level in myometrium and fibroids from women with and without preoperative treatment with a gonadotrophin-releasing hormone (GnRH) agonist for 3 months, from post-menopausal women, from pregnant women and in myometrium from women without fibroid disease. Women with menstrual periods were classified according to the phase of the cycle. In tissues from non-treated premenopausal women, IGF-I mRNA expression was significantly higher in fibroids than in myometrium, with no differences related to phase of the menstrual cycle. In post-menopausal women and in GnRH agonist-treated women responding to treatment, similar mRNA expression was seen in myometrium and fibroids but the concentrations were lower than in untreated premenopausal women. The IGF-I mRNA value in fibroids from pregnant women was higher than in any other group and myometrium from pregnant women exhibited higher mRNA expression than myometrium from non-treated premenopausal women. The IGF-I protein was more abundant in fibroids than in myometrium of non-treated premenopausal and of pregnant women and in both tissues the concentration was significantly higher in the group of pregnant women. The IGF-I protein concentrations in fibroids and myometrium from GnRH agonist-treated and post-menopausal women were similar to those from premenopausal non-treated women. High sex steroid concentrations in pregnant and non-pregnant women of fertile age seem to be associated with a higher expression of IGF-I in fibroids than in myometrium, suggesting that IGF-I contributes to the selective growth advantage of these tumours. | lld:pubmed |
| pubmed-article:11006320 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11006320 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11006320 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11006320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11006320 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11006320 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11006320 | pubmed:issn | 1360-9947 | lld:pubmed |
| pubmed-article:11006320 | pubmed:author | pubmed-author:GustavssonII | lld:pubmed |
| pubmed-article:11006320 | pubmed:author | pubmed-author:CarlströmKK | lld:pubmed |
| pubmed-article:11006320 | pubmed:author | pubmed-author:LindblomBB | lld:pubmed |
| pubmed-article:11006320 | pubmed:author | pubmed-author:SjöblomPP | lld:pubmed |
| pubmed-article:11006320 | pubmed:author | pubmed-author:EnglundKK | lld:pubmed |
| pubmed-article:11006320 | pubmed:author | pubmed-author:BlanckAA | lld:pubmed |
| pubmed-article:11006320 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11006320 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:11006320 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11006320 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11006320 | pubmed:pagination | 915-20 | lld:pubmed |
| pubmed-article:11006320 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11006320 | pubmed:meshHeading | pubmed-meshheading:11006320... | lld:pubmed |
| pubmed-article:11006320 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11006320 | pubmed:articleTitle | Gene expression and tissue concentrations of IGF-I in human myometrium and fibroids under different hormonal conditions. | lld:pubmed |
| pubmed-article:11006320 | pubmed:affiliation | Department of Obstetrics and Gynecology, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:11006320 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11006320 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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