Linked Life Data

11006320

Source:http://linkedlifedata.com/resource/pubmed/id/11006320

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2000-10-18
pubmed:abstractText
The expression of insulin-like growth factor-I (IGF-I) was measured at the mRNA and protein level in myometrium and fibroids from women with and without preoperative treatment with a gonadotrophin-releasing hormone (GnRH) agonist for 3 months, from post-menopausal women, from pregnant women and in myometrium from women without fibroid disease. Women with menstrual periods were classified according to the phase of the cycle. In tissues from non-treated premenopausal women, IGF-I mRNA expression was significantly higher in fibroids than in myometrium, with no differences related to phase of the menstrual cycle. In post-menopausal women and in GnRH agonist-treated women responding to treatment, similar mRNA expression was seen in myometrium and fibroids but the concentrations were lower than in untreated premenopausal women. The IGF-I mRNA value in fibroids from pregnant women was higher than in any other group and myometrium from pregnant women exhibited higher mRNA expression than myometrium from non-treated premenopausal women. The IGF-I protein was more abundant in fibroids than in myometrium of non-treated premenopausal and of pregnant women and in both tissues the concentration was significantly higher in the group of pregnant women. The IGF-I protein concentrations in fibroids and myometrium from GnRH agonist-treated and post-menopausal women were similar to those from premenopausal non-treated women. High sex steroid concentrations in pregnant and non-pregnant women of fertile age seem to be associated with a higher expression of IGF-I in fibroids than in myometrium, suggesting that IGF-I contributes to the selective growth advantage of these tumours.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1360-9947
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
915-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11006320-Adult, pubmed-meshheading:11006320-Aged, pubmed-meshheading:11006320-Antineoplastic Agents, Hormonal, pubmed-meshheading:11006320-Estradiol, pubmed-meshheading:11006320-Female, pubmed-meshheading:11006320-Follicle Stimulating Hormone, pubmed-meshheading:11006320-Gene Expression, pubmed-meshheading:11006320-Gonadotropin-Releasing Hormone, pubmed-meshheading:11006320-Goserelin, pubmed-meshheading:11006320-Humans, pubmed-meshheading:11006320-Insulin-Like Growth Factor I, pubmed-meshheading:11006320-Leiomyoma, pubmed-meshheading:11006320-Menopause, pubmed-meshheading:11006320-Menstrual Cycle, pubmed-meshheading:11006320-Middle Aged, pubmed-meshheading:11006320-Myometrium, pubmed-meshheading:11006320-Pregnancy, pubmed-meshheading:11006320-Progesterone, pubmed-meshheading:11006320-RNA, Messenger
pubmed:year
2000
pubmed:articleTitle
Gene expression and tissue concentrations of IGF-I in human myometrium and fibroids under different hormonal conditions.
pubmed:affiliation
Department of Obstetrics and Gynecology, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't