Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-10-12
pubmed:abstractText
Histochemical analysis of balloon-injured rat carotid arteries revealed a coordinated expression of nonmuscle myosin heavy chain-A and -B (NM-A and NM-B) in response to injury. Expression of these nonmuscle myosin forms shifts from the media to the adventitia and intima. In contrast, expression of smooth muscle myosin heavy chain-1 (SM-1) within the media is not altered, whereas smooth muscle myosin heavy chain-2 (SM-2) expression declines. Western blotting shows a statistically significant increase in expression of NM-A that occurs within 6 h in response to carotid injury, suggesting this myosin form may be an appropriate experimental marker for proliferating, migrating cells in injured vessels. No overall change in the relative expression level of NM-B was detected, suggesting that compensatory declines in media expression are balanced by increases in the intima and adventitia. Expression of SM-1 did not change in response to injury, whereas the expression of SM-2 significantly declined between 24 h and 7 days. Expression of myosin light chain kinase is also negatively regulated, and the decline in its expression parallels downregulation of SM-2.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-10347096, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-10364214, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-1534657, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-1577772, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-1700896, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-1735150, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-1899200, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-1995631, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-2145187, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-2347923, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-2438275, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-2681193, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-2892941, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-6371894, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-7493932, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-7503753, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-7624392, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-7749812, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-7778883, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-7916668, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-7923625, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-8205695, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-8464739, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-8569174, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9118482, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9126650, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9128257, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9147985, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9160829, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9172072, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9180010, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9180013, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9225203, http://linkedlifedata.com/resource/pubmed/commentcorrection/11003588-9236421
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0363-6143
pubmed:author
pubmed:issnType
Print
pubmed:volume
279
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
C1078-87
pubmed:dateRevised
2011-5-5
pubmed:meshHeading
pubmed-meshheading:11003588-Animals, pubmed-meshheading:11003588-Antibody Specificity, pubmed-meshheading:11003588-Blotting, Western, pubmed-meshheading:11003588-Carotid Artery, External, pubmed-meshheading:11003588-Carotid Artery Injuries, pubmed-meshheading:11003588-Down-Regulation, pubmed-meshheading:11003588-Immunohistochemistry, pubmed-meshheading:11003588-Male, pubmed-meshheading:11003588-Molecular Motor Proteins, pubmed-meshheading:11003588-Muscle, Smooth, Vascular, pubmed-meshheading:11003588-Myosin Heavy Chains, pubmed-meshheading:11003588-Myosin-Light-Chain Kinase, pubmed-meshheading:11003588-Myosins, pubmed-meshheading:11003588-Nonmuscle Myosin Type IIB, pubmed-meshheading:11003588-RNA, Messenger, pubmed-meshheading:11003588-Rats, pubmed-meshheading:11003588-Rats, Sprague-Dawley, pubmed-meshheading:11003588-Tunica Intima, pubmed-meshheading:11003588-Tunica Media, pubmed-meshheading:11003588-Up-Regulation, pubmed-meshheading:11003588-Wounds, Nonpenetrating
pubmed:year
2000
pubmed:articleTitle
Alterations in expression of myosin and myosin light chain kinases in response to vascular injury.
pubmed:affiliation
Department of Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. pgallag@iupui.edu
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