Linked Life Data

11000456

Source:http://linkedlifedata.com/resource/pubmed/id/11000456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2000-12-4
pubmed:abstractText
The highly conserved NspA protein has been found in the outer membrane of every Neisseria meningitidis strain tested so far. Two monoclonal antibodies (MAbs) directed against this protein were used to demonstrate that biologically important epitopes of the NspA protein are exposed at the surface of serologically distinct meningococcal strains. Analysis of sera collected from mice that survived a deadly meningococcal challenge following immunization with recombinant NspA protein (rNspA) revealed the presence of cross-reactive antibodies which efficiently attached to and killed the four serogroup B strains tested. These data are additional proof that the NspA protein is exposed at the surface of intact meningococcal cells, which is an important characteristic for a vaccine candidate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0168-1656
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-31
pubmed:dateRevised
2004-6-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Candidate Neisseria meningitidis NspA vaccine.
pubmed:affiliation
Unite de Recherche en Vaccinologie, Centre Hospitalier Universitaire de Québec, Pavillon CHUL et Université Laval, Sainte-Foy, G1V 4G2, Québec, Canada. denis.martin@crchul.ulaval.ca
pubmed:publicationType
Journal Article