Linked Life Data

10997797

Source:http://linkedlifedata.com/resource/pubmed/id/10997797

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-12-26
pubmed:abstractText
The antithrombotic activity of a fucosylated chondroitin sulfate extracted from the body wall of a sea cucumber was assessed using a stasis thrombosis model in rats. Intravenous administration of the polysaccharide reduced thrombosis in a dose-dependent manner. We also compared the antithrombotic action of the sea cucumber chondroitin sulfate with that of standard mammalian glycosaminoglycans, mainly heparin and dermatan sulfate. Intravascular injection of fucosylated chondroitin sulfate at the dose totally preventing thrombus formation produced a much more intense modification of the plasma anticoagulant activity than antithrombotic doses of unfractionated heparin, low-molecular-weight heparin and mammalian dermatan sulfate. Thus, it is possible that the mechanism of antithrombotic action of these polysaccharides are different. For fucosylated chondroitin sulfate, it depends mostly on modifications of the plasma anticoagulant activity, but it may involve additional effects in the case of mammalian glycosaminoglycans, perhaps modifications induced in the cells of the vessel wall. The anticoagulant and possibly the antithrombotic actions of fucosylated chondroitin sulfate are mostly dependent on heparin cofactor II activity, and both are markedly reduced with the decrease of the chain size of the polymer. Overall, the sulfated polysaccharide from the invertebrate revealed an unequivocal effect in preventing experimental venous thrombosis, is a useful tool to investigate the antithrombotic action in mammals and may offer an alternative for future development of a new therapeutic agent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0957-5235
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
563-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10997797-Animals, pubmed-meshheading:10997797-Anticoagulants, pubmed-meshheading:10997797-Carbohydrate Sequence, pubmed-meshheading:10997797-Chondroitin Sulfates, pubmed-meshheading:10997797-Dermatan Sulfate, pubmed-meshheading:10997797-Disease Models, Animal, pubmed-meshheading:10997797-Dose-Response Relationship, Drug, pubmed-meshheading:10997797-Echinodermata, pubmed-meshheading:10997797-Female, pubmed-meshheading:10997797-Fibrinolytic Agents, pubmed-meshheading:10997797-Fucose, pubmed-meshheading:10997797-Glycosaminoglycans, pubmed-meshheading:10997797-Heparin, pubmed-meshheading:10997797-Male, pubmed-meshheading:10997797-Molecular Sequence Data, pubmed-meshheading:10997797-Molecular Weight, pubmed-meshheading:10997797-Partial Thromboplastin Time, pubmed-meshheading:10997797-Rats, pubmed-meshheading:10997797-Sulfur Radioisotopes, pubmed-meshheading:10997797-Thrombosis
pubmed:year
2000
pubmed:articleTitle
Different antithrombotic mechanisms among glycosaminoglycans revealed with a new fucosylated chondroitin sulfate from an echinoderm.
pubmed:affiliation
Laboratório de Tecido Conjuntivo, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't