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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2000-10-17
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pubmed:abstractText |
We describe the isolation and characterisation of novel non-benzoquinone ansamycin metabolites related to geldanamycin from a culture of Streptomyces sp. S6699. The compounds possess potent inhibitory activity in a cell-based assay measuring inhibition of oncostatin M signalling in a reporter cell line utilising a secreted placental alkaline phosphatase (sPAP) readout. In this paper we report the isolation and structure elucidation of the compounds and describe some of their biological properties.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams, Macrocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/OSM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Oncostatin M,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Quinones,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rifabutin,
http://linkedlifedata.com/resource/pubmed/chemical/geldanamycin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-8820
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pubmed:author |
pubmed-author:BlackabyA PAP,
pubmed-author:BurrellFF,
pubmed-author:DavidsonII,
pubmed-author:DeakinAA,
pubmed-author:JonesRR,
pubmed-author:LatifSS,
pubmed-author:LewisJJ,
pubmed-author:LienJJ,
pubmed-author:MandelRR,
pubmed-author:SidebottomP JPJ,
pubmed-author:SpaullJJ,
pubmed-author:SteadPP,
pubmed-author:TaylorN LNL
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
657-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10994806-Alkaline Phosphatase,
pubmed-meshheading:10994806-Anti-Bacterial Agents,
pubmed-meshheading:10994806-Benzoquinones,
pubmed-meshheading:10994806-Cell Line,
pubmed-meshheading:10994806-Cell Survival,
pubmed-meshheading:10994806-Drug Evaluation, Preclinical,
pubmed-meshheading:10994806-Humans,
pubmed-meshheading:10994806-Inhibitory Concentration 50,
pubmed-meshheading:10994806-Interleukin-6,
pubmed-meshheading:10994806-Lactams, Macrocyclic,
pubmed-meshheading:10994806-Lung,
pubmed-meshheading:10994806-Oncostatin M,
pubmed-meshheading:10994806-Peptides,
pubmed-meshheading:10994806-Protein Biosynthesis,
pubmed-meshheading:10994806-Proteins,
pubmed-meshheading:10994806-Quinones,
pubmed-meshheading:10994806-Recombinant Proteins,
pubmed-meshheading:10994806-Rifabutin,
pubmed-meshheading:10994806-Signal Transduction,
pubmed-meshheading:10994806-Streptomyces
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pubmed:year |
2000
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pubmed:articleTitle |
Discovery of novel ansamycins possessing potent inhibitory activity in a cell-based oncostatin M signalling assay.
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pubmed:affiliation |
GlaxoWellcome Medicines Research Centre, Stevenage, Herts, UK.
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pubmed:publicationType |
Journal Article
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