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rdf:type |
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lifeskim:mentions |
umls-concept:C0000768,
umls-concept:C0003069,
umls-concept:C0007194,
umls-concept:C0011923,
umls-concept:C0026336,
umls-concept:C0027045,
umls-concept:C0034493,
umls-concept:C0035028,
umls-concept:C0040300,
umls-concept:C0086418,
umls-concept:C0554756,
umls-concept:C1383860
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pubmed:issue |
12
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pubmed:dateCreated |
2000-10-19
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pubmed:abstractText |
Hypertrophic cardiomyopathy (HCM) is diagnosed clinically by the presence of left ventricular hypertrophy (LVH). However, LVH is absent in a significant number of genotype-positive patients. Because myocyte dysfunction and disarray are the primary abnormalities in HCM, we reasoned that tissue Doppler imaging could identify contraction and relaxation abnormalities, irrespective of hypertrophy, in a transgenic rabbit model of human HCM.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1346-50
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:10993850-Analysis of Variance,
pubmed-meshheading:10993850-Animals,
pubmed-meshheading:10993850-Animals, Genetically Modified,
pubmed-meshheading:10993850-Blood Flow Velocity,
pubmed-meshheading:10993850-Cardiomyopathy, Hypertrophic,
pubmed-meshheading:10993850-Coronary Circulation,
pubmed-meshheading:10993850-Disease Models, Animal,
pubmed-meshheading:10993850-Echocardiography,
pubmed-meshheading:10993850-Humans,
pubmed-meshheading:10993850-Mitral Valve,
pubmed-meshheading:10993850-Mutation,
pubmed-meshheading:10993850-Myocardial Contraction,
pubmed-meshheading:10993850-Myosin Heavy Chains,
pubmed-meshheading:10993850-Observer Variation,
pubmed-meshheading:10993850-Pulmonary Valve,
pubmed-meshheading:10993850-Rabbits,
pubmed-meshheading:10993850-Sensitivity and Specificity
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pubmed:year |
2000
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pubmed:articleTitle |
Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy.
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pubmed:affiliation |
Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. sherifn@bcm.tmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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