10974354

Source:http://linkedlifedata.com/resource/pubmed/id/10974354

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C1280500, umls-concept:C1720776
pubmed:issue	7
pubmed:dateCreated	2000-11-16
pubmed:abstractText	Kindling produces enduring changes in the brain that are evident in not only enhanced susceptibility to seizure-evoking stimuli but also alterations in non-epileptic behaviors or functions. The present review examines the effects of kindling on one class of non-epileptic functions, learning and memory, and explores the dependence of these effects on variables such as the site of kindling, extent of kindling, and interval between kindling and testing. Current research shows that kindling is capable of altering performance on a variety of tasks including those that require spatial cognition, aversive conditioning, and object-related cognition and that non-mnemonic effects are unlikely, in at least some cases, to underlie these effects. Consideration of the conditions under which these effects are observed indicates a distinct relation between specific mnemonic effects and both the site and extent of kindling. Continued characterization of the mnemonic effects of kindling should provide a theoretical framework to guide discovery of their underlying mechanisms, which, in turn, may lead to rational therapy for mnemonic dysfunction associated with epilepsy and insights into the mechanisms of learning and memory.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7806090
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0149-7634
pubmed:author	pubmed-author:CorcoranM EME, pubmed-author:HannessonD KDK
pubmed:issnType	Print
pubmed:volume	24
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	725-51
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:10974354-Animals, pubmed-meshheading:10974354-Brain, pubmed-meshheading:10974354-Kindling, Neurologic, pubmed-meshheading:10974354-Memory, pubmed-meshheading:10974354-Space Perception
pubmed:year	2000
pubmed:articleTitle	The mnemonic effects of kindling.
pubmed:affiliation	Department of Psychology and Psychiatry, Neuropsychiatric Research Unit, University of Saskatchewan, 103 Wiggins Road, Sask, S7N 5E4, Saskatoon, Canada.
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't