To evaluate the function of cholecystokinin B (CCKB)/gastrin receptors in the rat kidney, we identified the receptors by Northern blot and localized the receptors by immunohistochemistry. The functional effects of gastrin were studied under standardized in vitro conditions using the isolated perfused kidney.
Department of Medicine, Divisions of Nephrology and Clinical Chemistry, University Hospital Eppendorf, Hamburg, and Institute of Pathology, University of Rostock, Rostock, Germany. schrenck@uke.uni-hamburg.de