10965248

Source:http://linkedlifedata.com/resource/pubmed/id/10965248

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0025255, umls-concept:C0110610, umls-concept:C0349702
pubmed:issue	5
pubmed:dateCreated	2000-10-3
pubmed:abstractText	We studied the localization and distribution of connective tissue growth factor (CTGF) in corneal scar tissue and membranes using in situ hybridization in 8 corneas from keratoplasty and 4 normal corneas. Identification of the cells was done with immunohistochemistry for SM-alpha-actin, vimentin, and Lu5. CTGF mRNA was found in activated corneal fibroblasts in 7 of 8 scars, 7 of 8 retrocorneal membranes and 2 subepithelial membranes, whereas the control corneas showed no CTGF mRNA expression. Vimentin was positive in all scars, retrocorneal and subepithelial membranes, SM-alpha-actin in 7 of 8 scars and 6 of 8 retrocorneal membranes. These results suggest that CTGF plays a crucial role in corneal wound healing and membrane formation.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0054655
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Actins, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/CTGF protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances, http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Vimentin
pubmed:status	MEDLINE
pubmed:issn	0030-3755
pubmed:author	pubmed-author:FlammerJJ, pubmed-author:MeyerPP, pubmed-author:PechMM, pubmed-author:ReiserPP, pubmed-author:SennB CBC, pubmed-author:WunderlichKK
pubmed:copyrightInfo	Copyright 2000 S. Karger AG, Basel
pubmed:issnType	Print
pubmed:volume	214
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	341-6
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:10965248-Actins, pubmed-meshheading:10965248-Biological Markers, pubmed-meshheading:10965248-Carrier Proteins, pubmed-meshheading:10965248-Cicatrix, pubmed-meshheading:10965248-Connective Tissue Growth Factor, pubmed-meshheading:10965248-Cornea, pubmed-meshheading:10965248-Corneal Diseases, pubmed-meshheading:10965248-Eye Injuries, Penetrating, pubmed-meshheading:10965248-Growth Substances, pubmed-meshheading:10965248-Humans, pubmed-meshheading:10965248-Immediate-Early Proteins, pubmed-meshheading:10965248-In Situ Hybridization, pubmed-meshheading:10965248-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:10965248-Keratoplasty, Penetrating, pubmed-meshheading:10965248-Prognosis, pubmed-meshheading:10965248-RNA, Messenger, pubmed-meshheading:10965248-Vimentin, pubmed-meshheading:10965248-Wound Healing
pubmed:articleTitle	Connective tissue growth factor in retrocorneal membranes and corneal scars.
pubmed:affiliation	University Eye Clinic and Institute of Pathology, University of Basel, Basel, Switzerland.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't