| pubmed-article:10962207 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10962207 | lifeskim:mentions | umls-concept:C0752336 | lld:lifeskim |
| pubmed-article:10962207 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10962207 | lifeskim:mentions | umls-concept:C0016693 | lld:lifeskim |
| pubmed-article:10962207 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:10962207 | lifeskim:mentions | umls-concept:C0524828 | lld:lifeskim |
| pubmed-article:10962207 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:10962207 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10962207 | pubmed:dateCreated | 2000-10-18 | lld:pubmed |
| pubmed-article:10962207 | pubmed:abstractText | Cat's claw (Uncaria tomentosa) is a medicinal plant from the Amazon River basin that is widely used for inflammatory disorders and was previously described as an inhibitor of NF-kappaB. Cat's claw was prepared as a decoction (water extraction) of micropulverized bark with and without concentration by freeze-drying. Murine macrophages (RAW 264.7 cells) were used in cytotoxicity assays (trypan blue exclusion) in response to the free radical 1, 1-diphenyl-2-picrilhydrazyl (DPPH, 0.3 microM) and ultraviolet light (UV) light. TNFalpha production was induced by lipopolysaccharide (LPS 0.5 microg/ml). Cat's claw was an effective scavenger of DPPH; the EC(50) value for freeze-dried concentrates was significantly less than micropulverized (18 vs. 150 microg/ml, p <.05). Cat's claw (10 microg/ml freeze-dried) was fully protective against DPPH and UV irradiation-induced cytotoxicity. LPS increased TNFalpha media levels from 3 to 97 ng/ml. Cat's claw suppressed TNFalpha production by approximately 65-85% (p <.01) but at concentrations considerably lower than its antioxidant activity: freeze-dried EC(50) = 1.2 ng/ml, micropulverized EC(50) = 28 ng/ml. In conclusion, cat's claw is an effective antioxidant, but perhaps more importantly a remarkably potent inhibitor of TNFalpha production. The primary mechanism for cat's claw anti-inflammatory actions appears to be immunomodulation via suppression of TNFalpha synthesis. | lld:pubmed |
| pubmed-article:10962207 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10962207 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10962207 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10962207 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10962207 | pubmed:issn | 0891-5849 | lld:pubmed |
| pubmed-article:10962207 | pubmed:author | pubmed-author:RobertsJJ | lld:pubmed |
| pubmed-article:10962207 | pubmed:author | pubmed-author:MillerM JMJ | lld:pubmed |
| pubmed-article:10962207 | pubmed:author | pubmed-author:SandovalMM | lld:pubmed |
| pubmed-article:10962207 | pubmed:author | pubmed-author:CharbonnetR... | lld:pubmed |
| pubmed-article:10962207 | pubmed:author | pubmed-author:TrentacostiA... | lld:pubmed |
| pubmed-article:10962207 | pubmed:author | pubmed-author:OkuhamaN NNN | lld:pubmed |
| pubmed-article:10962207 | pubmed:author | pubmed-author:KrenovaZZ | lld:pubmed |
| pubmed-article:10962207 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10962207 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10962207 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:10962207 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10962207 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10962207 | pubmed:pagination | 71-8 | lld:pubmed |
| pubmed-article:10962207 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:meshHeading | pubmed-meshheading:10962207... | lld:pubmed |
| pubmed-article:10962207 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10962207 | pubmed:articleTitle | Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. | lld:pubmed |
| pubmed-article:10962207 | pubmed:affiliation | Department of Pediatrics and Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA. sandovm@mail.amc.edu | lld:pubmed |
| pubmed-article:10962207 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10962207 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10962207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10962207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10962207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10962207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10962207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10962207 | lld:pubmed |
