Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2000-9-14
pubmed:abstractText
Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-10458613, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-10495277, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-10759892, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-10839546, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-10839547, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-1354393, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-1681108, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-1845916, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-1997210, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-2035528, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-7536897, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-7544754, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-7925474, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-8095043, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-8247133, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-8500166, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-8501199, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-8882295, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-8903723, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9108096, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9256468, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9275085, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9294199, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9338788, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9371744, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9384569, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9584186, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9626496, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9710609, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9843208, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9851976, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9853827, http://linkedlifedata.com/resource/pubmed/commentcorrection/10950864-9988214
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1997-2002
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
The Dlk1 and Gtl2 genes are linked and reciprocally imprinted.
pubmed:affiliation
Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't