Linked Life Data

10938383

Source:http://linkedlifedata.com/resource/pubmed/id/10938383

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-11-20
pubmed:abstractText
It has been demonstrated that vascular endothelial growth factor (VEGF) is associated with tumor progression as an angiogenic factor in esophageal squamous cell carcinoma (SCC)s. However, the role of other angiogenic factors such as transforming growth factor-alpha (TGF-alpha), platelet-derived endothelial cell growth factor (PD-ECGF), and basic fibroblast growth factor (bFGF) are still unknown in esophageal SCCs. In this study, we detected the expression of VEGF, TGF-alpha, PD-ECGF and bFGF in tissue specimens from 96 patients with SCC of the esophagus by immunohistochemical staining. To evaluate angiogenesis, endothelial cells were stained immunohistochemically and microvessel density (MVD) was counted in 24 cases. The positive rates for VEGF, TGF-alpha, PD-ECGF and bFGF were 65% (62/96), 67% (64/96), 66% (63/96), and 49% (47/96), respectively. Only TGF-alpha expression had a strong correlation with the average MVD (p=0.0059). However, the MVD increased as the number of positive factors for these 4 factors increased (p=0.0023). The expression of all of these factors significantly correlated to the depth of tumor invasion, and lymph node metastasis. Finally, survival analysis of the patients revealed that VEGF, TGF-alpha, and PD-ECGF were significant prognostic factors. However, multivariate analysis revealed that these factors were not prognostic. Thus, we suggest that TGF-alpha as well as VEGF, PD-ECGF and bFGF may be associated with angiogenesis, and the progression and metastasis of esophageal squamous cell carcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1019-6439
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
453-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10938383-Adult, pubmed-meshheading:10938383-Aged, pubmed-meshheading:10938383-Aged, 80 and over, pubmed-meshheading:10938383-Carcinoma, Squamous Cell, pubmed-meshheading:10938383-Endothelial Growth Factors, pubmed-meshheading:10938383-Esophageal Neoplasms, pubmed-meshheading:10938383-Female, pubmed-meshheading:10938383-Fibroblast Growth Factor 2, pubmed-meshheading:10938383-Gene Expression Regulation, Neoplastic, pubmed-meshheading:10938383-Humans, pubmed-meshheading:10938383-Lymphokines, pubmed-meshheading:10938383-Male, pubmed-meshheading:10938383-Middle Aged, pubmed-meshheading:10938383-Neoplasm Proteins, pubmed-meshheading:10938383-Neovascularization, Pathologic, pubmed-meshheading:10938383-Prognosis, pubmed-meshheading:10938383-Thymidine Phosphorylase, pubmed-meshheading:10938383-Transforming Growth Factor alpha, pubmed-meshheading:10938383-Vascular Endothelial Growth Factor A, pubmed-meshheading:10938383-Vascular Endothelial Growth Factors
pubmed:year
2000
pubmed:articleTitle
TGF-alpha as well as VEGF, PD-ECGF and bFGF contribute to angiogenesis of esophageal squamous cell carcinoma.
pubmed:affiliation
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan.
pubmed:publicationType
Journal Article, Comparative Study