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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-8-22
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pubmed:abstractText |
The tumor necrosis factor (TNF)-alpha/TNF receptor system is critical for liver development because hepatocytes undergo apoptosis if the antiapoptotic cascades resulting in RelA NF-kappaB activation are not effective. Therefore, we studied the role of TNF-alpha in fulminant hepatic failure (FHF) and developed a new therapeutic strategy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome c Group,
http://linkedlifedata.com/resource/pubmed/chemical/FADD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fadd protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fas-Associated Death Domain Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
446-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10930380-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10930380-Adenoviridae,
pubmed-meshheading:10930380-Animals,
pubmed-meshheading:10930380-Antigens, CD95,
pubmed-meshheading:10930380-Apoptosis,
pubmed-meshheading:10930380-Carrier Proteins,
pubmed-meshheading:10930380-Caspase 3,
pubmed-meshheading:10930380-Caspases,
pubmed-meshheading:10930380-Cytochrome c Group,
pubmed-meshheading:10930380-Disease Models, Animal,
pubmed-meshheading:10930380-Fas-Associated Death Domain Protein,
pubmed-meshheading:10930380-Gene Therapy,
pubmed-meshheading:10930380-Humans,
pubmed-meshheading:10930380-In Situ Nick-End Labeling,
pubmed-meshheading:10930380-Liver,
pubmed-meshheading:10930380-Liver Failure,
pubmed-meshheading:10930380-Mice,
pubmed-meshheading:10930380-Mice, Inbred BALB C,
pubmed-meshheading:10930380-Mitochondria,
pubmed-meshheading:10930380-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10930380-Recombinant Proteins,
pubmed-meshheading:10930380-Specific Pathogen-Free Organisms,
pubmed-meshheading:10930380-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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