Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-2
pubmed:abstractText
The use of oral contraceptives (OC) causes disturbances of the procoagulant, anticoagulant and fibrinolytic pathways of blood coagulation which may contribute to the increased risk of venous thrombosis associated with OC therapy. Here we report the results of a cycle-controlled randomized cross-over study, in which we determined the effects of so-called second and third generation OC's on a number of anticoagulant parameters. In this study, 28 non-OC using women were randomly prescribed either a second generation (150 microg levonorgestrel/30 microg ethinylestradiol) or a third generation OC (150 microg desogestrel/30 microg ethinylestradiol) and who switched to the other OC after a two month wash out period. The anticoagulant parameters determined were: antithrombin (AT), alpha2-macroglobulin (alpha2-M), alpha1-antitrypsin, protein C inhibitor (PCI), protein C, total and free protein S and activated protein C sensitivity ratios (APC-sr) measured with two functional APC resistance tests which quantify the effect of APC on either the activated partial thromboplastin time (aPTT) or on the endogenous thrombin potential (ETP). During the use of desogestrel-containing OC the plasma levels of alpha2-M, alpha1-antitrypsin, PCI and protein C significantly increased, whereas AT and protein S significantly decreased. Similar trends were observed with levonorgestrel-containing OC, although on this kind of OC the changes in AT, PCI and protein S (which was even slightly increased) did not reach significance. Compared with levonorgestrel, desogestrel-containing OC caused a significant decrease of total (p <0.005) as well as free protein S (p <0.0001) and more pronounced APC resistance in both the aPTT (p = 0.02) and ETP-based (p <0.0001) APC resistance tests. These observations indicate that the activity of the anticoagulant pathways in plasma from users of desogestrel-containing OC is more extensively impaired than in plasma from users of levonorgestrel-containing OC.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antithrombins, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Combined, http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Hormonal, http://linkedlifedata.com/resource/pubmed/chemical/Desogestrel, http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol, http://linkedlifedata.com/resource/pubmed/chemical/Levonorgestrel, http://linkedlifedata.com/resource/pubmed/chemical/Protein C, http://linkedlifedata.com/resource/pubmed/chemical/Protein C Inhibitor, http://linkedlifedata.com/resource/pubmed/chemical/Protein S, http://linkedlifedata.com/resource/pubmed/chemical/Thrombin, http://linkedlifedata.com/resource/pubmed/chemical/alpha 1-Antitrypsin, http://linkedlifedata.com/resource/pubmed/chemical/alpha-Macroglobulins
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0340-6245
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10928463-Activated Protein C Resistance, pubmed-meshheading:10928463-Adolescent, pubmed-meshheading:10928463-Adult, pubmed-meshheading:10928463-Antithrombins, pubmed-meshheading:10928463-Biological Markers, pubmed-meshheading:10928463-Blood Coagulation, pubmed-meshheading:10928463-Blood Proteins, pubmed-meshheading:10928463-Contraceptives, Oral, Combined, pubmed-meshheading:10928463-Contraceptives, Oral, Hormonal, pubmed-meshheading:10928463-Cross-Over Studies, pubmed-meshheading:10928463-Desogestrel, pubmed-meshheading:10928463-Ethinyl Estradiol, pubmed-meshheading:10928463-Female, pubmed-meshheading:10928463-Humans, pubmed-meshheading:10928463-Levonorgestrel, pubmed-meshheading:10928463-Netherlands, pubmed-meshheading:10928463-Partial Thromboplastin Time, pubmed-meshheading:10928463-Protein C, pubmed-meshheading:10928463-Protein C Inhibitor, pubmed-meshheading:10928463-Protein S, pubmed-meshheading:10928463-Thrombin, pubmed-meshheading:10928463-Thrombophilia, pubmed-meshheading:10928463-alpha 1-Antitrypsin, pubmed-meshheading:10928463-alpha-Macroglobulins
pubmed:year
2000
pubmed:articleTitle
A randomized cross-over study on the effects of levonorgestrel- and desogestrel-containing oral contraceptives on the anticoagulant pathways.
pubmed:affiliation
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't