|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0019564,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021760,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0109317,
umls-concept:C0332281,
umls-concept:C0678558,
umls-concept:C0752312,
umls-concept:C1150579,
umls-concept:C1280500,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1705767,
umls-concept:C1705791
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2000-8-17
|
|
pubmed:abstractText |
Several cytokines have short-term effects on synaptic transmission and plasticity that are thought to be mediated by the activation of intracellular protein kinases. We have studied the effects of interleukin-6 (IL-6) on the expression of paired pulse facilitation (PPF), posttetanic potentiation (PTP), and long-term potentiation (LTP) in the CA1 region of the hippocampus as well as on the activation of the signal transducer and activator of transcription-3 (STAT3), the mitogen-activated protein kinase ERK (MAPK/ERK), and the stress-activated protein kinase/c-Jun NH(2)-terminal kinase (SAPK/JNK). IL-6 induced a marked and dose-dependent decrease in the expression of PTP and LTP that could be counteracted by the simultaneous treatment with the tyrosine kinase inhibitor lavendustin A (LavA) but did not significantly affect PPF. The IL-6-induced inhibition of PTP and LTP was accompanied by a simulation of STAT3 tyrosine phosphorylation and an inhibition of MAPK/ERK dual phosphorylation, in the absence of changes in the state of activation of SAPK/JNK. Both effects of IL-6 on STAT3 and MAPK/ERK activation were effectively counteracted by LavA treatment. The results indicate the tyrosine kinases and MAPK/ERK are involved in hippocampal synaptic plasticity and may represent preferential intracellular targets for the actions of IL-6 in the adult nervous system.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/lavendustin A
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-3042
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
75
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
634-43
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10899938-Animals,
pubmed-meshheading:10899938-DNA-Binding Proteins,
pubmed-meshheading:10899938-Enzyme Inhibitors,
pubmed-meshheading:10899938-Excitatory Postsynaptic Potentials,
pubmed-meshheading:10899938-Hippocampus,
pubmed-meshheading:10899938-Interleukin-6,
pubmed-meshheading:10899938-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10899938-Kinetics,
pubmed-meshheading:10899938-Male,
pubmed-meshheading:10899938-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10899938-Neuronal Plasticity,
pubmed-meshheading:10899938-Phenols,
pubmed-meshheading:10899938-Pyramidal Cells,
pubmed-meshheading:10899938-Rats,
pubmed-meshheading:10899938-Rats, Wistar,
pubmed-meshheading:10899938-STAT3 Transcription Factor,
pubmed-meshheading:10899938-Synapses,
pubmed-meshheading:10899938-Synaptic Transmission,
pubmed-meshheading:10899938-Trans-Activators
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK.
|
|
pubmed:affiliation |
Department of Neuroscience, University of Roma Tor Vergata, Roma, Italy.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
