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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5477
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pubmed:dateCreated |
2000-7-25
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pubmed:abstractText |
Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
289
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-70
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10894769-Animals,
pubmed-meshheading:10894769-Arthritis,
pubmed-meshheading:10894769-Base Sequence,
pubmed-meshheading:10894769-Biological Transport,
pubmed-meshheading:10894769-COS Cells,
pubmed-meshheading:10894769-Calcinosis,
pubmed-meshheading:10894769-Chromosome Mapping,
pubmed-meshheading:10894769-Cloning, Molecular,
pubmed-meshheading:10894769-DNA,
pubmed-meshheading:10894769-Diphosphates,
pubmed-meshheading:10894769-Durapatite,
pubmed-meshheading:10894769-Gene Expression,
pubmed-meshheading:10894769-Genetic Complementation Test,
pubmed-meshheading:10894769-Humans,
pubmed-meshheading:10894769-Membrane Proteins,
pubmed-meshheading:10894769-Mice,
pubmed-meshheading:10894769-Mice, Transgenic,
pubmed-meshheading:10894769-Molecular Sequence Data,
pubmed-meshheading:10894769-Mutation,
pubmed-meshheading:10894769-Phenotype,
pubmed-meshheading:10894769-Phosphate Transport Proteins,
pubmed-meshheading:10894769-Physical Chromosome Mapping,
pubmed-meshheading:10894769-Sequence Homology, Nucleic Acid,
pubmed-meshheading:10894769-Tissue Distribution
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pubmed:year |
2000
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pubmed:articleTitle |
Role of the mouse ank gene in control of tissue calcification and arthritis.
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pubmed:affiliation |
Department of Developmental Biology and Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, CA 94305-5327, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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