Linked Life Data

10891885

Source:http://linkedlifedata.com/resource/pubmed/id/10891885

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-8-31
pubmed:abstractText
We now know that tumor necrosis factor (TNF) family ligands regulate development of lymphoid tissue and coordinate cellular differentiation to defend against intracellular pathogens. In particular, TNF provides essential signals for the formation of secondary lymphoid tissue structures and plays an important role in several physiological and pathological conditions that relate to its action in inflammation and leukocyte movement. The TNF-related family of membrane-anchored and secreted ligands also represents a major mechanism regulating cell death and cell survival. TNF was first described as an endotoxin-induced and macrophage secreted factor that caused haemorrhagic necrosis of tumor cells. Over the past two decades we have come to appreciate that T lymphocytes and natural killer (NK) cells also produce TNF, yet no clear single role for lymphocyte-derived TNF has emerged. This review describes the key molecular details of the action of TNF and discusses the evidence for TNF-mediated cytotoxicity being critical to lymphocyte function and immunoregulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1059-910X
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
196-208
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Role of TNF in lymphocyte-mediated cytotoxicity.
pubmed:affiliation
Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin. m.smyth@pmci.unimelb.edu.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't