Source:http://linkedlifedata.com/resource/pubmed/id/10886512
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2000-8-15
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| pubmed:abstractText |
Interleukin-17 is a T-cell-derived cytokine, detected in skin affected by allergic contact dermatitis and psoriasis, which regulates keratinocyte expression of adhesion molecules and chemokines. In this study, we have analyzed whether interleukin-17 production segregates with a particular T helper (Th) cell subset, and have examined the capacity of interleukin-17 to modulate the activation of keratinocytes induced by Th1 and Th2 cytokines. A panel of 80 nickel-specific CD4+ T cell clones (36 Th0, 30 Th1, and 14 Th2) was isolated from peripheral blood or lesional skin of allergic contact dermatitis patients. Significant amounts (> 50 pg per ml) of interleukin-17 were released by about 50% of activated Th0, Th1, and Th2 cells. Interleukin-17 alone and in cooperation with interleukin-4, or to a lesser extent with interferon-gamma, decreased the interleukin-1 receptor antagonist to interleukin-1alpha ratio in the supernatants as well as in cell lysates from keratinocytes. In addition, interleukin-17 stimulated the release of growth-regulated oncogene-alpha, granulocyte-macrophage colony stimulating factor, and interleukin-6, with synergistic or additive effects when used together with interferon-gamma or interleukin-4. Interleukin-17 and interleukin-4 also increased stem cell factor release, a function that was inhibited by interferon-gamma. Moreover, interleukin-17 and interleukin-4 enhanced interferon-gamma-induced expression of intercellular adhesion molecule 1, but not CD40, on keratinocytes. The constitutive expression of interleukin-17 and interferon-gamma receptors on keratinocytes was not modulated by interleukin-17, interferon-gamma, or interleukin-4, whereas the interleukin-4 receptor was significantly downregulated by interferon-gamma. As a whole, the results indicate that interleukin-17 can participate relevantly in T-cell-mediated skin immune responses by amplifying both interferon-gamma- and interleukin-4-induced activation of keratinocytes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Nickel,
http://linkedlifedata.com/resource/pubmed/chemical/Stem Cell Factor
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0022-202X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
115
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
81-7
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10886512-Chemokine CXCL1,
pubmed-meshheading:10886512-Chemokines, CXC,
pubmed-meshheading:10886512-Chemotactic Factors,
pubmed-meshheading:10886512-Clone Cells,
pubmed-meshheading:10886512-Dermatitis, Allergic Contact,
pubmed-meshheading:10886512-Epitopes,
pubmed-meshheading:10886512-Growth Substances,
pubmed-meshheading:10886512-Humans,
pubmed-meshheading:10886512-Immunity, Cellular,
pubmed-meshheading:10886512-Intercellular Adhesion Molecule-1,
pubmed-meshheading:10886512-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:10886512-Interferon-gamma,
pubmed-meshheading:10886512-Interleukin-17,
pubmed-meshheading:10886512-Interleukin-4,
pubmed-meshheading:10886512-Keratinocytes,
pubmed-meshheading:10886512-Nickel,
pubmed-meshheading:10886512-Psoriasis,
pubmed-meshheading:10886512-Stem Cell Factor,
pubmed-meshheading:10886512-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:10886512-Th1 Cells,
pubmed-meshheading:10886512-Th2 Cells
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| pubmed:year |
2000
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| pubmed:articleTitle |
Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes.
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| pubmed:affiliation |
Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy. c.albanesi@idi.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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