Source:http://linkedlifedata.com/resource/pubmed/id/10879293
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2000-8-7
|
| pubmed:abstractText |
Tracheal reconstruction after extensive resection remains an unsolved surgical problem. Numerous attempts have been made using tracheal grafts or prosthetic conduits with disappointing results. In this study, we propose a new alternative using an aortic autograft as tracheal substitute. In a first series of experiments, a half circumference of two rings was replaced with an autologous carotid artery patch. In a second series, a complete segment of trachea was replaced with an autologous aortic graft supported by an endoluminal tracheal stent. No dehiscence or stenosis was observed. Microscopic examinations at 3 and 6 months showed the replacement of the aortic tissue by tracheal tissue comprising neoformation of cartilage and mucociliary or non-keratinizing metaplastic polystratified squamous epithelium. Although these results need to be confirmed by a larger series of experiments, they showed that a vascular tissue placed in a different environment with a different function can be submitted to a metaplastic transformation which tends to restore a normal structure adapted to its new function. These remarkable findings offer new perspectives in tracheal reconstruction in human.
|
| pubmed:language |
fre
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0764-4469
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
323
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
455-60
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10879293-Animals,
pubmed-meshheading:10879293-Aorta, Thoracic,
pubmed-meshheading:10879293-Carotid Arteries,
pubmed-meshheading:10879293-Cartilage,
pubmed-meshheading:10879293-Cell Differentiation,
pubmed-meshheading:10879293-Cell Movement,
pubmed-meshheading:10879293-Cilia,
pubmed-meshheading:10879293-Dyspnea,
pubmed-meshheading:10879293-Epithelium,
pubmed-meshheading:10879293-Granuloma,
pubmed-meshheading:10879293-Metaplasia,
pubmed-meshheading:10879293-Postoperative Complications,
pubmed-meshheading:10879293-Sheep,
pubmed-meshheading:10879293-Stents,
pubmed-meshheading:10879293-Surgical Wound Dehiscence,
pubmed-meshheading:10879293-Trachea,
pubmed-meshheading:10879293-Transplantation, Autologous,
pubmed-meshheading:10879293-Transplantation, Heterotopic,
pubmed-meshheading:10879293-Wound Healing
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
[Metaplasia of aortic tissue into tracheal tissue. Surgical perspectives].
|
| pubmed:affiliation |
Laboratoire d'étude des greffes et prothèses cardiaques, Hôpital Broussais, Paris, France.
|
| pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|